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This book offers a historical perspective on the scientific milestones that have brought IVF to its current prominence and explores future directions based on ongoing research.
As we approach fifty years of IVF, this book reflects on the journey of a procedure that evolved from modest beginnings to a cornerstone of modern clinical care. Initially, years passed between successful pregnancies, but today, 2-4% of all births globally result from ART procedures. IVF stands out as one of the few medical interventions that effectively addressed the clinical problem it was designed to solve-sterility. Originally intended for women with blocked fallopian tubes, IVF soon revealed its potential to evaluate and manipulate oocytes and embryos, addressing a growing array of clinical needs.
This book will benefit professionals in the field of reproductive endocrinology and infertility and OBGYN as well as trainees. It may also be appealing the couples going through IVF treatments and the general public. Readers may find in the book the historical origins of current day practice as well as and updated and future prospects.
Dr. Yaakov Bentov, MD, M.SC., Reproductive Endocrinology & Infertility Specialist (REI)
Dr. Yaakov Bentov earned his Medical Degree at Ben Gurion University in Israel. As a medical student, he founded a bachelor's program in Emergency Medicine for paramedics, and later served as its Program Head. He had also pursued a master's degree in medical business administration (MBA) while completing his residency in Obstetrics Gynecology (1995-2002). Both programs were at Ben Gurion University.
After completing his residency, he came to Toronto to complete a fellowship in Reproductive Endocrinology and Infertility (REI) at the University of Toronto.
He later took the roles of medical director of the Ontario based Juno Fertility clinics as well as an associate REI & a research director at ANOVA fertility.
Dr. Bentov is an currently a senior REI in the Department of Obstetrics and Gynecology at Hadassah Mt. Scopus in Jerusalem. He pursues research in the areas of ovarian function and pathology, infertility, and reproductive endocrinology.
Dr. Bentov has published research in more than 70 peer reviewed publications and is an editor for several leading medical journals.
Anat Hershko Klement MD Reproductive Endocrinology & Infertility Specialist (REI)
Dr Anat Hershko-Klement completed her Obstetrics & Gynecology residency in 2010 and was later a postgraduate in reproductive endocrinology and infertility in Toronto. She is currently the head of the reproduction and IVF unit in Hadassah mount Scopus. Her special research interests are epidemiological aspects of ART and IVF pregnancy outcomes. She is involved in medical education and was leading the post-graduate school for reproductive endocrinology and infertility of the Israeli Fertility association between 2019-2022, as well as a member in the Israeli board exams in Obstetrics and Gynecology Dr. Hershko Klement has published 44 original articles , 23 of them as a principal investigator.
Part I.- History of IVF - Early days.- History of cryopreservation.-Part II History of IVF related pharma.- Clomiphene Citrate & Aromatase inhibitors in IVF.- Gonadotropins in IVF.- GnRH agonists in IVF.- IVF Protocols.-Part III.- From SUZI to ICSI.- Embryo Assessment: Morphology & morphokinetiks.- Embryo Assessment: PGT.- Fertility preservation.-Part IV Future predictions.- The next half century.- Global trends in fertility & fecundity.- Implications of Overturning of Roe V. Wade on IVF.- Embryo assessment - AOD.- DOR/POI.- Embryo enhancement ( Mitochondrial transfer, KRISPER).
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