Part I: Biological Characterization of Bone Tissue.- Chapter 1. Bone: functions, structure and physiology.- Chapter 2. Bone Quality Assessment at the Atomic Scale.- Part II: Bone Remodelling algorithms.- Chapter 3. Meshless, Bone Remodelling and Bone Regeneration Modelling.- Chapter 4. Dynamic biochemical and cellular models of bone physiology: integrating remodeling processes, tumor growth and therapy.- Chapter 5. Mathematical Modelling of Spatio-Temporal cell dynamics observed during Bone Remodelling.- Chapter 6. A Mechanostatistical Approach to Multiscale Computational Bone Remodelling.- Part III: Numerical simulation of bone tissue and adjacent structures.- Chapter 7. Finite Element Analysis of Bone and Experimental Validation.- Chapter 8. Computational modelling of tissue engineered cartilage constructs.- Chapter 9. On the Computational Biomechanics of the Intervertebral Disc.- Index.