Section 1 - The Clinical Problem.- Clinical associations of recurrent miscarriage.- The epidemiology of repeated abortion.- Discussion.- A prospective study of spontaneous abortion.- Discussion.- Clinical and immunological significance of anti-phospholipid antibodies.- Discussion.- Section 2 - Experimental Models of Early Pregnancy Failure.- Anatomical and immunological aspects of fetal death in the Mus musculus/Mus caroli model of pregnancy failure.- Discussion.- Genetic aspects of the CBA × DBA/2 and B1O × B10.A models of murine pregnancy failure and its prevention by lymphocyte immunisation.- Discussion.- Effects of feto-maternal major histocompatibility differences on litter size in pigs.- Discussion.- A non-genetic development defect in trophoblast formation in the horse: immunological aspects of a model of early abortion.- Discussion.- Section 3 - Studies of the Normal and Failing Placenta in Early Pregnancy.- Placental pathology in spontaneous miscarriage.- Discussion.- Early human trophoblast.- Discussion.- The decidua in early pregnancy.- Discussion.- Early pregnancy failure: biochemical and biophysical assessment.- Discussion.- Haemostasis and fibrinolysis in human normal placentae: possible role in early pregnancy failure.- Discussion.- Section 4 - Factors Which Maintain Pregnancy at and Immediately After Implantation.- Chairman's introductory remarks.- Antigen expression by cells of the conceptus before, during and after implantation.- Discussion.- Host immunoregulatory mechanisms and the success of the conceptus fertilised in vivo and in vitro.- Discussion.- Interplay of oestrogens, progesterone and polypeptide growth factors at about the time of implantation.- Discussion.- Prostaglandins and other non-steroidal mediators at and immediatelyafter implantation.- Discussion.- Section 5 - Genetic Causes of Early Pregnancy Failure.- Is there a t complex in man?.- Discussion.- Immunogenetic factors influencing the survival of the fetal allograft.- Discussion.- The cytogenetics of spontaneous abortion in humans.- Discussion.- The biology of trophoblastic disease: complete and partial hydatidiform moles.- Discussion.- Section 6 - Techniques, Treatment Criteria and Outcome of Immunotherapy in Recurrent Abortion.- Chairman's introductory remarks.- Successes and failures of immunisation for recurrent spontaneous abortion.- Discussion.- Pregnancy outcome in couples with recurrent abortions following immunological evaluation and therapy.- Discussion.- Belgian experience with repeat immunisation in recurrent spontaneous abortions.- Discussion.- Immunotherapy in recurrent spontaneous abortion: who, how, outcome.- Discussion.- Human MHC antigens and paternal leucocyte injections in recurrent spontaneous abortions.- Discussion.- Trophoblast membrane infusion (TMI) in the treatment of recurrent spontaneous abortion.- Discussion.- Section 7 - Other Methods of Treatment.- Use of cervical cerclage in patients with recurrent first trimester abortion.- Discussion.- Early recurrent pregnancy failure: treatment with human chorionic gonadotrophin.- Discussion.- Recurrent abortion: the role of psychotherapy.- Discussion.
