Neurodegenerative Diseases

Part I. Basic Aspects of Neurodegeneration: 1. Endogenous free radicals and antioxidants in the brain; 2. Biological oxidants and therapeutic antioxidants; 3. Mitochondria, metabolic inhibitors and neurodegeneration; 4. Excitotoxicity and excitatory amino acid antagonists in chronic neurodegenerative diseases; 5. Glutamate transporters; 6. Calcium binding proteins in selective vulnerability of motor neurons; 7. Apoptosis in neurodegenerative diseases; 8. Neurotrophic factors; 9. Protein misfolding and cellular defence mechanisms in neurodegenerative diseases; 10. Neurodegenerative disease and the repair of oxidatively damaged DNA; 11. Compounds acting on ion channels; 12. The role of nitric oxide and PARP in neuronal cell death; 13. Copper and zinc in Alzheimer's disease and amyotrophic lateral sclerosis; 14. The role of inflammation in Alzheimer's disease neuropathology and clinical dementia: from epidemiology to treatment; 15. 15. Selected genetically engineered models relevant to human neurodegenerative disease; 16. Toxic animal models; 17. A genetic outline of the pathways to cell death in Alzheimer's disease, Parkinson's disease, frontal dementias and related disorders; 18. Neurophysiology of Parkinson's disease, levodopa-induced dyskinesias, dystonia, Huntington's disease and Myoclonus; Part II. Neuroimaging in Neurodegeneration: 19. Structural and functional magnetic resonance imaging in neurodegenerative diseases; 20. PET/SPECT; 21. Magnetic resonance spectroscopy of neurodegenerative illness; Part III. Therapeutic Approaches in Neurodegeneration: 22. Gene therapy; 23. Stem cells and cell-based therapy in neurodegenerative disease; 24. Necessary methodological and stem cell advances for restoration of the dopaminergic system in Parkinson's disease patients; Part IV. Normal Aging: 25. Clinical aspects of normal aging; 26. Neuropathology of normal aging in cerebral cortex; Part V. Alzheimer's Disease: 27. Mild cognitive impairment; 28. Alzheimer's disease - overview; 29. The neuropathology of Alzheimer's disease in the year 2005; 30. Genetics of Alzheimer's disease; 31. The role of Beta-amyloid in Alzheimer's disease; 32. Treatment of Alzheimer's disease; Part VI. Other Dementias: 33. Dementia with Lewy bodies; 34. Frontotemporal lobar degeneration; 35. Frontotemporal dementia with Parkinsonism linked to Chromosome 17; 36. Prion diseases; Part VII. Parkinson's and Related Movement Disorders: 37. Approach to the patient presenting with Parkinsonism; 38. Parkinson's disease; 39. Neuropathology of Parkinson's disease; 40. Genetics of Parkinsonism; 41. Pathophysiology - biochemistry of Parkinson's disease; 42. Current and potential treatments of Parkinson's disease; 43. Multiple system atrophy; 44. Progressive supranuclear palsy; 45. Corticobasal degeneration; Part VIII. Cerebellar Degenerations: 46. Approach to the patient with ataxia; 47. Autosomal dominant cerebellar ataxia; 48. Friedreich's ataxia and other autosomal recessive ataxias; 49. Ataxia telangiectasia; Part IX. Motor Neuron Diseases: 50. An approach to the patient with motor neuron dysfunction; 51. The genetics of amyotrophic lateral sclerosis; 52. Current and potential therapeutics in motor neuron diseases; 53. The hereditary spastic paraplegias; 54. Spinal and Bulbar muscular atrophy (Kennedy's disease); 55. Spinal muscular atrophies; 56. Western Pacific ALS/Parkinsonism-Dementia complex; Part X. Other Neurodegenerative Diseases: 57. Huntington's disease; 58. Dentatorubral-pallidoluysian atrophy (DRPLA): model for Huntington's disease and other polyglutamine diseases; 59. Neuroacanthocytosis; 60. Brain iron disorders; 61. Neurological aspects of Wilson's disease; 62. Disorders of the mitochondrial respiratory chain; Index.