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This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field.
Written by experts in their field, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists,pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis, and related autoimmune disorders.
Daniel C. Baumgart, MD
Inflammatory Bowel Disease Center
Department of Gastroenterology and Hepatology
Charité Medical Center--Virchow Hospital
Medical School of the Humboldt University of Berlin
Berlin, Germany
Foreword.- Preface.- Environmental Factors in the Epidemiology of Inflammatory Bowel Disease.- The Immune System in Health.- Understanding the Epithelial Barrier in IBD.- Intestinal Microbiology and Ecology in Crohn's Disease and Ulcerative Colitis.- The Immune System in Inflammatory Bowel Disease: Antimicrobial Peptides.- Vascular Responses to Intestinal Inflammation.- Immunobiology of Human Dendritic Cells in Inflammatory Bowel Disease.- Immunobiology of T-cells in Inflammatory Bowel Disease.- Immunology of B-cells in Inflammatory Bowel Disease.- Immune Cells: Monocytes and Macrophages.- Immune Functions of Epithelial Cells in Inflammatory Bowel Disease.- Autophagy and Endoplasmic Reticulum Stress.- Matrix Metalloproteinases.- Paradigm of T-cell Differentiation in Irritable Bowel Disease.- Pharmacological Intervention Studies Using Mouse Models of Chronic Intestinal Inflammation.- Stem Cells and Organoids to Study Epithelial Cell Biology in Inflammatory Bowel Disease.- Enhanced Endoscopy.- Magnetic Resonance Enterography.- Computed Tomography Enterography and Inflammatory Bowel Disease.- Ultrasound in Inflammatory Bowel Disease.- Laboratory Evaluation, Including Novel Diagnostic Markers.- Pathology of Inflammatory Bowel Disease.- Objective Assessment of Clinical Disease Activity.- Objective Assessment of Endoscopic Disease Activity and Mucosal Healing.- Evaluation of Quality of Life in Crohn's Disease and Ulcerative Colitis: What Is Health-Related Quality of Life?.- Evaluation of Health Economics in Inflammatory Bowel Disease.- The Natural History of Inflammatory Bowel Disease.- Conventional Medical Management of Crohn's Disease: Sulfasalazine.- Steroid Therapy for Crohn's Disease.- Thiopurines in Crohn's Disease.- Conventional Medical Management of Crohn's Disease: Methotrexate.- Adalimumab for the Treatment of Crohn's Disease.- Biologic Therapy of Crohn's Disease: Certolizumab.- Biologic Therapy of Crohn's Disease: Infliximab.- Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment.- Biologic Therapy of Crohn's Disease: Natalizumab, Vedolizumab and anti-MadCAM.- Optimal Management of Fistulizing Crohn's Disease.- Sulfasalazine and 5-aminosalicylates for Ulcerative Colitis.- Conventional Therapy of Ulcerative Colitis: Corticosteroids.- Medical Management of Ulcerative Colitis: Conventional Therapy-Azathioprine.- Calcineurin Inhibitors in Ulcerative Colitis.- Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab.- Biologic Therapy of Ulcerative Colitis: Adalimumab.- Biologic Therapy of Ulcerative Colitis: Golimumab.- Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab beta 7), antiMadCAM.- Probiotics, Prebiotics, and Antibiotics in Inflammatory Bowel Disease.- Biosimilars in the Treatment of Inflammatory Bowel Disease.- Step-up versus Top-down Approach in Crohn's Disease.- Leukocytapheresis Therapy of Inflammatory Bowel Diease.- Surgical Management of Crohn's Disease and Ulcerative Colitis.- Extraintestinal Manifestations: Autoimmune Hepatitis.- Primary Sclerosing Cholangitis.- Autoimmune Pancreatitis and Other Organ Involvement.- Cutaneous and Oral Manifestations of Inflammatory Bowel Disease.- Arthritis, Arthropathy and Osteoporosis in Inflammatory Bowel Disease.- Nutrition in Inflammatory Bowel Disease.- Pregnancy and Fertility in Inflammatory Bowel Disease.- Pediatric Aspects of Inflammatory Bowel Disease.- Management and Prevention of Infectious Diseases in Inflammatory Bowel Disease Patients.- Incidence of Cancer and Screening in Inflammatory Bowel Disease.- Inflammatory Bowel Diseases: How to Identify High Risk Patients.- Patient Perspective on Inflammatory Bowel Disease.- Patient Resources in Inflammatory Bowel Disease.
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