Huntington's Disease

Table of Contents Section 1: Clinical aspects of Huntington's disease 1. Huntington's Disease in a Historical Context Peter S Harper 2. Clinical Neurology of Huntington's disease Raymund AC Roos 3. Neuropsychiatry and Neuropsychology David Craufurd and Julie Snowden 4. Juvenile Huntington's disease Oliver W J Quarrell 5. Premanifest and Early Huntington's Disease Edward J Wild and Sarah J Tabrizi Section 2: The genetics of Huntington's disease 6. Huntington's disease: genetic and molecular studies Cécile Cazeneuve and Alexandra Durr 7. The Epidemiology of Huntington's Disease Chris Kay, Emily Fisher, Michael R. Hayden 8. Genetic Counselling and Testing Rhona MacLeod and Aad Tibben Section 3: Neurobiology 9. The Neuropathology of Huntington's Disease in the Human Brain Henry J Waldvogel, Eric H Kim, Lynette J Tippett, Jean-Paul G Vonsattel, and Richard LM Faull 10. Altered Neuronal Circuitry in Huntington's Disease Michael S. Levine, Elizabeth A. Wang, Jane Y. Chen, Carlos Cepeda, and Véronique M. André Section 4: The molecular biology of Huntington's disease 11. The normal function of huntingtin Chiara Zuccato and Elena Cattaneo 12. Order, disorder, and conformational flux in the structural biology of Huntington's Disease Ronald Wetzel and Rakesh Mishra 13. Pathogenic mechanisms in Huntington's disease Alis Hughes and Lesley Jones 14. Peripheral pathology in Huntington's disease Authors: Jorien M.M. van der Burg, N. Ahmad Aziz, Maria Björkqvist Section 5: Therapeutic interventions in Huntington's disease 15. Comprehensive care in Huntington's disease Martha A. Nance 16. Preclinical Experimental Therapeutics in Huntington's Disease Gillian P. Bates and Christian Landles 17. Experimental Therapeutics in Huntington's Disease: Moving Forward in Clinical Trials Beth Borowsky and Cristina Sampaio