The Natural History of Rabies, Volume 1

List of ContributorsPrefaceContents of Volume IIChapter 1 History of Rabies Text ReferencesPart I The Virus Chapter 2 Morphology and Morphogenesis I. Morphology of Rabies Virus II. Morphogenesis of Rabies Virus III. The Bearing of Morphology and Morphogenesis on the Placement of Rabies Virus in the Rhabdovirus Group References Chapter 3 Antigenic Composition of Rabies Virus I. Introduction II. Rabies Antigen in Infected Cells III. Antigens of the Rabies Virion IV. Antigens of Disrupted Virions V. Soluble Antigen VI. Conclusion References Chapter 4 Chemical Composition and Structure of Rabies Virus I. Introduction II. Properties of the Virion III. Disruption of the Virus into Its Components IV. The Viral RNA V. Viral Structural Proteins VI. Intracellular Virus and Viral Components References Chapter 5 Hemagglutinin of Rabies Virus I. Introduction II. Optimal Conditions for Preparation and Demonstration of Hemagglutinin III. Characteristics of Hemagglutinin IV. Relationship between Hemagglutinating and Immunizing Capacity of Rabies Virus Particles V. Hemagglutination Inhibition Test References Chapter 6 Passive Hemagglutination Test I. Passive Hemagglutination Procedure II. Advantages of the Passive Hemagglutination Test III. Disadvantages of the Test References Chapter 7 Concentration and Purification I. Introduction II. Methods for Concentration III. Methods of Purification IV. Summary References Chapter 8 Rabies Virus Antigenic Relationships I. Introduction II. Antigenic Distinction between the Viruses of the Rabies Sero Group and Other Rhabdoviruses III. Rabies-Related Viruses IV. Antigenic Relationships in the Rabies Group V. Other Antigenic Variants of Rabies Virus VI. Significance of Rabies-Related Viruses ReferencesPart II Pathogenesis and Pathology Chapter 9 Growth of Rabies Virus in Cell Culture I. Introduction II. Historical Review III. Adaptation of Rabies Virus to Growth in Cell Culture IV. Chronic Infection of Cell Culture Systems V. Dynamics of Virus Replication in Vitro VI. Virus-Specific Products of Infected Cells VII. Virion-free Rabies Antigen (Soluble Antigen) (VFRA) VIII. Immune Lysis IX. Production of Interferon in Rabies Virus-Infected Cells X. Cytopathic Effect of Rabies Virus in Cell Cultures XI. Optimal Conditions for the Production of Rabies Virus in High Titer XII. Coinfection of Cells in Vitro with Rabies and Other Viruses XIII. Effect of Metabolic Inhibitors on Virus Replication in Vitro XIV. Alteration of Rabies Virus Phenotype as a Result of Passage in Cell Culture References Chapter 10 Pathogenesis to the Central Nervous System I. Pathogenesis after Subcutaneous or Intramuscular Introduction of Virus II. Pathogenesis after Intranasal Introduction of Virus III. Pathogenesis after Oral Administration IV. Pathogenesis after Intravenous Inoculation of Virus References Chapter 11 Spread of Virus within the Central Nervous System I. Demonstration of Infectivity II. Histopathology III. Immunofluorescence and Electron Microscopy IV. Clinical Signs V. Pathogenesis of Abortive and Chronic Infection VI. Summary and Prospects References Chapter 12 Electron Microscopy of Central Nervous System Infection Text References Chapter 13 The Pathology of Rabies in the Central Nervous System I. Microscopic Changes II.