The problem of electron transfer phosphorylation was first formu lated in 1939 by Belitser and Tsibakova I who introduced the "P: 0" criterion and showed that this ratio is more than 1. The authors noted that such a high value of the phosphorylation coefficient suggests a fundamental difference in the mechanisms of A TP formation coupled with respiration, and glycolysis, since in the latter case, the amount of the ATP synthesized is equal to that of the substrate utilized. A lot of hypothetical schemes were put forward to explain the nature of coupling between electron transfer and phosphorylation, but none of them solved the problem. Only quite recently, one hypo thetical scheme of energy coupling, viz. Mitchell's chemiosmotic concept, 2.3 was supported by experimental data which allow us to prefer it to alternative possibilities. In this paper, I shall try to substantiate the statement that oxidation and phosphorylation can be coupled via a membrane potential as was postulated by Mitchell.
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ISBN-13
978-1-4684-2016-6 (9781468420166)
DOI
10.1007/978-1-4684-2016-6
Schweitzer Klassifikation
A: Mechanisms of Biological Energy Transduction.- The Development of Bioenergetics.- Chemiosmotic Coupling in Energy Transduction: A Logical Development of Biochemical Knowledge.- Solution of the Problem of Energy Coupling in Terms of Chemiosmotic Theory.- A Model of Membrane Biogenesis.- Energy Transduction in the Functional Membrane of Photosynthesis: Results by Pulse Spectroscopic Methods.- Toward a Theory of Muscle Contraction.- Bioenergetics of Nerve Excitation.- An Analytical Appraisal of Energy Transduction Mechanisms.- Oxidative Phosphorylation, A History of Unsuccessful Attempts: Is It Only An Experimental Problem?.- On the Coupling of Electron Transport to Phosphorylation.- Functional Organization of Intramembrane Particles of Mitochondrial Inner Membranes.- On Energy Conservation and Transfer in Mitochondria.- An Enzymological Approach to Mitochondrial Energy Transduction.- ATP Synthesis in Oxidative Phosphorylation: A Direct-Union Stereochemical Reaction Mechanism.- The Electromechanochemical Model of Mitochondrial Structure and Function.- B: Membrane Structure.- The Relationship of the (Na+ + K+)-Activated Enzyme System to Transport of Sodium and Potassium Across the Cell Membrane.- On the Meaning of Effects of Substrate Structure on Biological Transport.- Performance and Conservation of Osmotic Work by Proton-Coupled Solute Porter Systems.- Molecular Basis for the Action of Macrocyclic Carriers on Passive Ionic Translocation Across Lipid Bilayer Membranes.- Mechanisms of Energy Conservation in the Mitochondrial Membrane.- Biogenesis of Mitochondria 23. The Biochemical and Genetic Characteristics of Two Different Oligomycin Resistant Mutants of Saccharomyces Cerevisiae Under the Influence of Cytoplasmic Genetic Modification.- A Physio-chemical Basis for Anion, Cation and Proton Distributions between Rat-liver Mitochondria and the Suspending Medium.- Microwave Hall Mobility Measurements on Heavy Beef Heart Mitochondria.- Possible Mechanisms for the Linkage of Membrane Potentials to Metabolism by Electrogenic Transport Processes with Special Reference to Ascaris Muscle.- The Effect of Redox Potential on the Coupling Between Rapid Hydrogen-Ion Binding and Electron Transport in Chromatophores from Rhodopseudomonas Spheroides.- A Note on Some Old and Some Possible New Redox Indicators.- The Role of Lipid-Linked Activated Sugars in Glycosylation Reactions.- Lipid-Protein Interactions in the Structure of Biological Membranes.- Structure-Function Unitization Model of Biological Membranes.- The Influence of Temperature-Induced Phase Changes on the Kinetics of Respiratory and Other Membrane-Associated Enzyme Systems.- Interactions at the Surface of Plant Cell Protoplasts; An Electrophoretic and Freeze-etch Study.
