Applications of NMR Spectroscopy Volume 7

Name: Applications of NMR Spectroscopy Volume 7
Brand: Bentham Science Publishers
Price: 61.37 EUR
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Atta-Ur-Rahman M. Iqbal Chaudhary(Herausgeber*in)

Bentham Science Publishers

1. Auflage

Erschienen am 3. April 2019

205 Seiten

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978-1-68108-641-5 (ISBN)

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Inhalt

Cover
Title
Biblography
End User License Agreement
Contents
Preface
List of Contributors
Atomic Structural Investigations of Self-Assembled Protein Complexes by Solid-State NMR
Antoine Loquet*, James Tolchard and Birgit Habenstein*
INTRODUCTION
SOLID-STATE NMR SAMPLE PREPARATION
Protein Expression
Protein Self-assembly
ssNMR Rotor Filling
GLOBAL ARCHITECTURE ASSESSMENT
ATOMIC STRUCTURE INVESTIGATIONS
Secondary Structure Determination - Solid-state NMR Resonance Assignment
Distance Restraint Collection - Intra- and Intermolecular Distances
Structure Modelling
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Assessing Liver Disease and the Gut Microbiome by NMR Metabolic Profiling of Body Fluids
I. Jane Cox1,2,*, Mark J.W. McPhail3 and Roger Williams1,2
INTRODUCTION
The Liver and Gut Microbiota
The Clinical Need for the Earlier Detection of Liver Disease
Bio-fluids Suitable for NMR Metabolic Profiling
NMR Facilities are Expanding
URINARY NMR STUDIES
Metabolites Detected
Detecting other Factors of Urinary Chemical Composition
Metabolites of Particular Interest
PLASMA AND SERUM NMR STUDIES
LIMITATIONS OF ANALYSING BODY FLUIDS
Confounding Factors
Sample Collection
Standardised NMR Acquisition Protocol
Clinical Practice
EXAMPLES OF NMR PROFILING IN LIVER DISEASE
Cirrhosis
Hepatic Encephalopathy
Hepatocellular Carcinoma
Gut Microbial Modulation in Chronic Liver Disease
Fecal Microbiota Transplantation
Liver Transplantation
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
GLOSSARY
REFERENCES
1H NMR: A Powerful Tool for Lipid Digestion Research
Bárbara Nieva-Echevarría, Encarnación Goicoechea and María D. Guillén*
1. INTRODUCTION
2. 1H NMR A VERY USEFUL TOOL FOR THE STUDY OF HYDROLYSIS DURING FOOD LIPID DIGESTION
2.1. Lipolysis Reactions Under Gastrointestinal Conditions and Relevance of their Study
2.2. Current Methodologies Employed to Study Lipolysis Reactions During Digestion
2.3. Use of 1H NMR to Study Qualitatively and Quantitatively Complex Lipid Mixtures of Glycerides and Fatty Acids
2.4. Quantification of the Several Lipolytic Species and Assessment of the Extent of Lipolysis by 1H NMR Spectroscopy in Real Digested Lipid Samples
2.4.1. Molar Percentages of Acyl Groups Bonded to the Several Kinds of Glycerides and of Fatty Acids in Relation to the Total Number of Acyl Groups Plus Fatty Acids
2.4.2. Molar Percentages of the Several Kinds of Glycerides Including Glycerol in Relation to the Total Number of Glyceryl Species
2.4.3. Determination of the Extent of Lipid Digestion from 1H NMR Spectral Data
3. 1H NMR A VERY USEFUL TOOL FOR THE STUDY OF LIPID OXIDATION DURING FOOD DIGESTION
3.1. Lipid Oxidation During Digestion: A Complex Reaction Recently Evidenced under these Physiological Conditions
3.2. Methodologies Employed to Study Lipid Oxidation During Digestion
3.3. Global Study by 1H NMR of Lipid Oxidation During Digestion
3.3.1. Degradation of Unsaturated Fatty Acids/Acyl Groups During Lipid In Vitro Digestion
3.3.2. Generation of Lipid Oxidation Products During Oil In Vitro Digestion
3.3.3. Estimation of in vitro Bioaccesibility of Lipid Main and Minor Components and Oxidation Products
4. CONCLUSIONS AND FUTURE PERSPECTIVES
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES
Nuclear Magnetic Resonance as an Attractive Resource for Monitoring Surveillance Candidates of Acute and Chronic Lung Disorders
Simona Viglio1, Cristina Airoldi2, Carlotta Ciaramelli2 and Paolo Iadarola3,*
INTRODUCTION TO METABOLOMICS
CHOICE OF THE BIOLOGICAL FLUIDS TO BE ANALYZED
SAMPLE COLLECTION AND HANDLING
METHODS OF SAMPLE PREPARATION
ACQUISITION OF SPECTRA AND DATA PROCESSING
CASE STUDIES
Taurine/Hypotaurine Metabolism
Metabolism of Short Chain (C2 to C4) Compounds
TCA Cycle Intermediates
Pyruvate/Lactate Metabolism
Amino Acid Metabolism
BCAAs Metabolism
Histidine Metabolism
Arginine Metabolism
Glutamate/Glutamine Metabolism
Other Amino Acids
Nitrogenous Bases, Nucleosides and Nucleotides
CONSIDERATIONS ON THE RELIABILITY AND ANALYSIS OF METABOLOMIC RESULTS IN THE STUDY OF RESPIRATORY DISORDERS
CONCLUDING REMARKS
CONSENT FOR PUBLICATION
ACKNOWLEDGEMENTS
CONFLICT OF INTEREST
REFERENCES
Decoding DNA Structure using NMR Spectroscopy
Mahima Kaushik1,2,*, Swati Chaudhary2, Sonia Khurana2, Komal Mehra2 and Shrikant Kukreti2
INTRODUCTION
Various Types of NMR Utilized for the Elucidation of DNA Structure
NMR Studies of Various DNA Topologies
DNA Duplex
Hairpin DNA
DNA Triplex
Guanine-Quadruplex
OUTLOOK AND FUTURE ASPECTS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Early Diagnosis of Cancer using Nuclear Magnetic Resonance Spectroscopy: A Novel Diagnostic Approach
Neetu Talreja1, Manjula Nair2 and Dinesh Kumar3,*
INTRODUCTION
Basic Principles of NMR Spectroscopy
NMR Spectroscopy in Metabonomics Determination
Current Status of NMR in Cancer Diagnosis
Cancer and Its Types
Breast Cancer
Lung Cancer
Prostate Cancer
Ovarian Cancer
Gastric Cancer
Growth-Associated Changes in the Energy Metabolism of the Cancer Cell
31P-NMR Spectra for Prediction and Detection of Therapeutic Response
FUTURE PROSPECTS AND CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
Back Cover

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