Advances in Immunology

Name: Advances in Immunology
Brand: Academic Press
Price: 138.0 EUR
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Frederick W. Alt(Herausgeber*in)

Academic Press

Erschienen am 25. Juni 2021

112 Seiten

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Front Cover
Advances in Immunology
Copyright
Contents
Contributors
Chapter One: The multi-faceted roles of TGF-ß in regulation of immunity to infection
1. Introduction
1.1. TGF-ß and the immune system
1.2. TGF-ß in infection
2. Viral infections
2.1. Influenza virus
2.2. LCMV virus
2.3. Hepatitis B virus
2.4. HIV infection
2.5. Coronavirus infections
2.6. Viral infections in general
3. Bacterial infections
3.1. Gram-negative bacteria
3.2. Gram-positive bacteria
3.3. Mycobacterium tuberculosis
4. Fungal infections
5. Protozoal parasite infections
5.1. Leishmania
5.2. Malaria
5.3. Toxoplasma
5.4. Trypanosoma cruzi
5.5. African trypamosomes
6. Helminth parasite infections
6.1. Filarial nematodes
6.2. Intestinal nematodes
6.3. Schistosomes and liver flukes
6.4. Tapeworms
7. Commensal microbiome
8. Pathogen exploitation of TGF-ß
8.1. Activation and potentiation of host TGF-ß
8.2. Induction of host cell TGF-ß production
8.3. Pathogen homologs and mimics
9. Conclusion
Acknowledgments
References
Chapter Two: Follicular lymphoma dynamics
1. Introduction
2. FL etiology: A dynamic process
2.1. Early steps of FL development
2.2. FL committed precursor cells (CPC) and subclinical disease
2.3. Memory B cells reactivation as a pathogenic mechanism of FL clonal evolution
3. GC and FL dynamics in the single-cell era
3.1. Gene expression profiling: From bulk analyses to single-cell resolution
3.2. Methods for integrative single-cell analyses of gene expression and BCR repertoire in B cells
3.3. Novel insights into GC biology from single-cell analyses
3.4. Single-cell transcriptomics analyses in FL
3.5. Intra-sample transcriptional diversity of malignant FL B cells
3.6. Future prospects of single-cell studies of FL
4. The role of epigenetics in FL dynamics
4.1. Epigenetic control of the GC
4.2. Genetics-driven disruption of epigenetic regulation in FL
4.3. The players
5. The role of the tumor microenvironment in FL dynamics
5.1. FL microenvironment: A double-edge sword
5.2. Immune response and immune escape in FL
5.3. FL tumor-supportive cell niches
5.4. FL microenvironment heterogeneity: Genetics and beyond
6. A new paradigm
7. Clinical and translational directions and perspectives
7.1. Current challenges of drug development in follicular lymphoma
7.1.1. Watch and wait
7.1.2. First line
7.1.3. Relapse
7.2. New biological learnings and technological advances provide opportunities for drug development in FL
Acknowledgments
References

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