Advances in Immunology

Name: Advances in Immunology
Brand: Academic Press
Price: 138.0 EUR
Availability: OnlineOnly

Frederick W. Alt(Herausgeber*in)

Academic Press

Erschienen am 13. Mai 2021

122 Seiten

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Inhalt

Intro
Advances in Immunology
Copyright
Contents
Contributors
Chapter One: Thymoproteasome optimizes positive selection of CD8 T cells without contribution of negative selection
1. Introduction
2. Overview of proteasomes
2.1. Proteasomes, immunoproteasomes, and thymoproteasomes
2.2. Substrate specificity of proteasomes affects MHC class I-associated peptides
3. Thymoproteasome for CD8 T cell generation
3.1. Discovery of ß5t and thymoproteasome
3.2. Impact of thymoproteasome on transcriptome and proteome in cTECs
3.3. Impact of ß5t deficiency on TCR repertoire in CD8 T cells
3.4. Thymic selection in the absence of negative selection
3.4.1. Thymic selection in the absence of medulla
3.4.2. Thymic selection in the microenvironment where only cTECs present antigens
3.4.3. Thymic selection independent of apoptosis-mediated negative selection
3.5. Thymoproteasome and peptide switch hypothesis
3.5.1. Peptide switch hypothesis
3.5.2. Thymoproteasome-dependent T cell generation independent of peptide switch
3.6. How does thymoproteasome work?
4. Concluding remarks
Acknowledgments
References
Chapter Two: Modeling a complex disease: Multiple sclerosis-Update 2020
1. Gray matter demyelination in multiple sclerosis
2. The influence of the microbiome on CNS autoimmunity
3. Identifying the pathogenic factor driving MS and EAE
4. Perspective and conclusion
References
Chapter Three: The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response
1. The SNAG domain transcription factors GFI1 and GFI1B
1.1. Discovery of GFI1 and GFI1B
1.2. Molecular mechanisms and interactions
1.3. LSD1: The critical cofactor for GFI1 and GFI1B
1.4. GFI1 in the DNA damage response
1.5. The KSKK motif in GFI1 and the effect on its activity
1.6. GFI1 in DNA repair
1.7. Downstream effectors of GFI1
1.8. Regulation of GFI1 expression and activity
2. GFI1 and GFI1B in thymic pre-T cell differentiation
2.1. T-cell commitment and NOTCH1 signaling
2.2. GFI1 in pre-TCR selection
2.3. MHC restricted positive/negative selection
2.4. GFI1 and GFI1B: Redundant or specific roles?
3. GFI1 in the activation and polarization of mature T cells and innate lymphoid cells
3.1. CD8 T cells
3.2. Th1 and Th2, CD4 T cells
3.3. CD4 Treg, Th17 and Th9 cells
3.4. NKT cells
3.5. Innate lymphoid cells
4. B cell commitment, differentiation and activation
4.1. GFI1 in early B cell development
4.2. Mature B cells and B cell activation require GFI1
5. GFI1 in innate immunity and the inflammatory response
5.1. GFI1 and myeloid differentiation
5.2. Requirement of Gfi1 for neutrophils
5.3. Dendritic cells
5.4. Inflammation and the TLR/NF?B signaling pathway
6. Conclusion and summary
Acknowledgments
References
Chapter Four: Panorama of stepwise involvement of the IgH 3 regulatory region in murine B cells
1. Structure of the IgH 3 boundary and associated regulatory region
2. Is the 3RR involved in early B cell development?
3. Involvement of the 3RR in Ig µ heavy chain production and B cell receptor expression
4. Individual 3IgH enhancers control CSR by providing accessibility of acceptor switch regions
5. Involvement of the quasi-palindromic structure in somatic hypermutation
6. Plasma cell Ig heavy chain production depends on the full palindromic IgH 3RR
7. Concluding remarks: Panorama of IgH 3RR stepwise activation
8. Remaining 3RR dark zones and future perspectives
Acknowledgments
Conflict of interest
References

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