Chemistry and Biological Activities of Ivermectin

Name: Chemistry and Biological Activities of Ivermectin
Brand: Wiley-Blackwell
Price: 168.99 EUR
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Rashid Ali Shahid-Ul-Islam(Herausgeber*in)

Wiley-Blackwell (Verlag)

1. Auflage

Erschienen am 1. September 2023

288 Seiten

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978-1-394-16802-6 (ISBN)

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Inhalt

Intro
Table of Contents
Series Page
Title Page
Copyright Page
Preface
1 Introduction to Ivermectin
1.1 Introduction
1.2 Sources and Synthesis
1.3 Pharmacological Potential of Ivermectin
1.4 Ivermectinâ?Ts Beneficial Role in Cattle
1.5 Ivermectin in the Treatment of COVID-19
1.6 Toxicity of Ivermectin
1.7 Conclusion
References
2 Historical Background of and Synthetic Approaches to Ivermectin (IVM) and its Homologues
2.1 Introduction
2.2 Synthetic Approaches Towards the Construction of IVM and Analogues
2.3 Biosynthesis
2.4 Chemical Synthetic Pathway
2.5 Crystal Structure
2.6 Conclusion and Outlook
Acknowledgements
References
3 Ivermectin as a Repurposed Drug for COVID-19
3.1 Introduction
3.2 Symptoms of COVID-19
3.3 Repurposing of the Drugs
3.4 Repurposed Drugs for COVID-19
3.5 Repurposing of Ivermectin for COVID-19
3.6 Proposed Possible Mechanism of Action
3.7 SARS COVID-19 Clinical Studies with Ivermectin
3.8 Conclusions
3.9 Acknowledgments
References
4 Ivermectin as an Anti-Parasitic Agent
Abbreviations
4.1 Introduction
4.2 Use of Ivermectin Against Various Human Parasitic Infections
4.3 Mode of Action Against Various Parasites
4.4 Conclusions
4.5 Acknowledgements
References
5 Emerging Paradigm of Ivermectin and its Hybrids in Elimination of Malaria
5.1 Introduction
5.2 Malaria
5.3 Life Cycle of Malaria
5.4 Drug Against Hepatic Malarial Stage
5.5 About Ivermectin
5.6 Designing and Synthesis of Ivermectin Inhibitors
5.7 Conclusions
5.8 Acknowledgments
References
6 Ivermectin: A Potential Repurposed Anti-Cancer Therapeutic
Abbreviations
6.1 Introduction
6.2 Mechanism of Anti-Carcinogenesis
6.3 Activation of Chloride Ion Channels
6.4 Anti-Mitotic Effect and Inhibition of Angiogenesis
6.5 Inhibition of Mitochondrial Respiration
6.6 Inhibitor of Cancer Stem Cells (CSCs)
6.7 Induction of Immunogenic Cell Death (ICD)
6.8 Epigenetic Modulator
6.9 Induction PAK1-Mediated Cytostatic Autophagy
6.10 Inhibition of P-glycoprotein (P-gp)
6.11 Inhibition of Yes-Associated Protein 1 (YAP1)
6.12 Inhibition of RNA Helicase
6.13 Caspase-Dependent Apoptosis
6.14 Activation of Transcription Factor E3 (TFE3)
6.15 Inhibition of Wnt-TCF Pathway Responses
6.16 Conclusions
References
7 Ivermectin as an Anti-Inflammatory Agent
7.1 Introduction
7.2 Ant-Inflammatory Action of Ivermectin
7.3 Conclusions
Acknowledgements
References
8 Ivermectin: An Anthelminthic and Insecticide
8.1 Introduction
8.2 Ivermectin as an Anthelmintic
8.3 Insecticidal Activity of Ivermectin
Conclusions
References
9 Potential Applications of Ivermectin (IVM) in Dermatology
9.1 Introduction
9.2 Mechanism of Action, Toxicity, and Side Effects of IVM
9.3 Motivational Approach of IVM in the Treatment of Skin
9.4 Role of IVM with Good Anti-Parasitic Properties Against the Infection of Skin
9.5 Importance of IVM as an Anti-Cancer or Anti-Tumor Agent in Curing the Skin
9.6 Social Value of IVM in the Medical Care of Red Scrotum Syndrome (RSS)
9.7 Utility of IVM as an Anti-Inflammatory Drug in the Treatment of Skin-Related Issues
9.8 Conclusions
Acknowledgements
References
10 Antiviral Uses of Ivermectin
10.1 Introduction
10.2 Mechanism of Action of Ivermectin
10.3 Anti-Viral Effects Against Various DNA and RNA Viruses
10.4 Conclusion
References
11 Toxicology, Safety, and Environmental Aspects of Ivermectin
11.1 Introduction
11.2 Ivermectinâ?Ts Antiparasitic Activity
11.3 Pharmacology
11.4 Adverse Effects in Humans and Animals
11.5 Ivermectin and Ectoparasites
11.6 Environmental Impact and Biodegradation of Ivermectin
11.7 Conclusion
References
Index
Also of Interest
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