RNA Nanostructures

Molecular Dynamics Simulations of RNA Motifs to Guide the Architectural Parameters and Design Principles of RNA Nanostructures.- Computer assisted design and characterization or RNA nanostructures.- Combining Experimental Restraints and RNA 3D Structure Prediction in RNA Nanotechnology.- Structural Characterization of Nucleic Acid Nanoparticles using SAXS and SAXS-driven MD.- Metalated Nucleic Acid Nanostructures.- Bioconjugation of Functionalized Oligodeoxynucleotides with Fluorescence Reporters for Nanoparticle Assembly.- Light-assisted drying for the thermal stabilization of nucleic acid nanoparticles and other biologics.- Preparation of Nucleic Acid Aptamer Functionalized Silver/Gold Nanoparticle Conjugates.- Thermodynamic Characterization of Nucleic Acid Nanoparticles Hybridization by UV Melting.- Structural Characterization of DNA Templated Silver Nanoclusters by Energy Dispersive Spectroscopy.- Small Volume microrheology to Evaluate Viscoelastic Properties of Nucleic Acid-based Hydrogels.- Characterization of RNA Nanoparticles and Their Dynamic Properties Using Atomic Force Microscopy.- Synthesis of Mesoporous Silica Nanoparticles for the Delivery of Nucleic Acid Nanostructures.- Assessment of intracellular compartmentalization of RNA nanostructures.- Discriminating immunorecognition pathways activated by RNA nanostructures.- Detection of nanoparticles' ability to stimulate toll-like receptors using HEK-Blue reporter cell lines.- Complexing PAMAM Dendrimers to Nucleic Acid Nanoparticles for their Intracellular Delivery.- Reverse transfection of functional RNA rings into cancer cells followed by in vitro irradiation.- RNA/DNA nanostructures designed for efficient regulation of blood coagulation.- Detection of multiplex NASBA RNA products using colorimetric split G quadruplex probes.- Synthesis of DNA-Templated Silver Nanoclusters and the Characterization of Their Optical Properties and Biological Activity.- Dynamic nanostructures for conditional activation and deactivation of biological pathways.- Anticoagulant activity of nucleic acid nanoparticles assessed by thrombin generation dynamics on a fully-automated system.