Advances in Pharmacology

Name: Advances in Pharmacology
Brand: Academic Press
Price: 54.95 EUR
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Academic Press

Erschienen am 2. Dezember 1991

373 Seiten

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978-0-08-058113-2 (ISBN)

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Inhalt

Cover
Contents
Contributors
Chapter 1. Acyclovir: Mechanism of Antiviral Action and Potentiation by Ri bonucleotide Reductase Inhibitors
I. Introduction
II. Acyclovir Transport
III. Metabolic Activation of Acyclovir
IV. Mechanism of Antiviral Action
V. Potentiation of the Antiviral Action of Acyclovir
VI. Resistance and Hypersensitivity to Acyclovir
VII. Conclusions
References
Chapter 2. Rational Approaches to Osteoporosis Therapy
I. Introduction
II. Age-Related Changes in Bone Mass
III. Mechanisms of Bone Mass Regulation
IV. Osteoporosis
V. Experimental Approaches
VI. Nonpharmacological Considerations
VII. Conclusions
References
Chapter 3. Molecular Asymmetry and Its Pharmacological Consequences
I. Introduction
II. Pharmacokinetic Consequences of Chirality
III. Chirality and Polymorphic Drug Disposition
IV. Pharmacodynamic Consequences of Chirality
V. Enantiomer-Enantiomer Interactions
VI. Enantioselective Drug-Enantiomer Interactions
VII. Enantiomeric Impurity and Potential Problems
VIII. Enantiomers as Biochemical Probes
IX. Therapeutic and Regulatory Considerations
X. Therapeutic Drug Monitoring
XI. Conclusions
References
Chapter 4. Blood-Brain Barrier: Transport Studies in Isolated Brain Capillaries and in Cultured Brain Endothelial Cells
I. Introduction
II. Establishment and Characterization of an in Vitro Blood-Brain Barrier Model
III. In Vitro Transport Studies
IV. In Vitro Studies on Regulation of Blood-Brain Barrier Transport
V. Summary
References
Chapter 5. Protein Kinase Inhibitors: Probes for the Functions of Protein Phosphorylation
I. Introduction
II. Inhibitors of Protein Serine/Threonine Kinases
III. Inhibitors of Protein Tyrosine Kinases
IV. Concluding Remarks
References
Chapter 6. Renin Inhibitors
I. Introduction
II. Physical and Functional Properties of Renin
III. Biochemical Evaluation and Specificity of Renin Inhibitors
IV. Design and Structure of Renin Inhibitors
V. Pharmacology of Renin Inhibitors
VI. Conclusion
References
Chapter 7. The Capacitative Model for Receptor-Activated Calcium Entry
I. Introduction
II. Epithelial Cells: Models for Studying Receptor-Activated Ca2+ Signaling
III. Mechanisms of Ca2+ Entry
IV. Conclusions
References
Chapter 8. Calcium Channel Antagonists in the Prevention of Neurotoxicity
I. Introduction
II. Potential Problems in Interpreting the Effectiveness of Calcium Channel Antagonists in Preventing Neurotoxicity
III. Types of Neurotoxicity Attenuated by Calcium Channel Antagonists
IV. The Hypothesis of Calcium-Associated Neuronal Damage
V. Potential Contribution of T, N, L, and P Types of Calcium Channels to Neurotoxicity
VI. Types of Voltage-Dependent Calcium Channel Antagonists
VII. In Vitro Models of Neurotoxicity and Effects of Calcium Channel Antagonists
VIII. In Vivo Animal Models of Ischemia and Effects of Calcium Channel Antagonists
IX. Early Human Trials and Prospects for Calcium Channel Antagonists in Preventing Neurotoxicity
X. Conclusions
References
Chapter 9. New Directions in the Delivery of Drugs and Other Substances to the Central Nervous System
I. Introduction
II. Altering the Barrier
III. Altering Agents
IV. Circumventing the Barrier
V. Conclusion
References
Chapter 10. Hormonal Regulation of Cytochrome P-450 Gene Expression
I. General Introduction
II. Cytochrome P-450 Nomenclature and Gene Structure
III. Transcriptional Regulation of Cytochrome P-450 Genes: Involvement of cis-Acting DNA Elements
IV. Hormonal Regulation of Cytochrome P-450 Involved in the Biosynthesis of Hormones
V. Regulation of Liver Cytochrome P-450 by Sex Steroids and Growth Hormone
VI. Regulation of Cytochrome P-450 in the Prostate, Pituitary, and Brain
VII. General Conclusions
VIII. Future Perspectives"Novel Endocrine Systems?
References
Index

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