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This book focuses on the fascinating topic of tumor microenvironment and dendritic cell immunotherapy. It provides readers with comprehensive insights into this field by offering detailed measurement protocols for assessing the biophysical characteristics of cells, along with bioinformatics analysis and mathematical modeling techniques to explore the initiation of dendritic cell-induced T cell immune responses within the tumor microenvironment. We also delve into the effects of chemical factors, mechanical stimulation, and traditional Chinese medicine on dendritic cells in this specific context. By delving into the intricate interactions between the tumor microenvironment and dendritic cells, readers will gain a profound understanding of tumor progression and the potential of dendritic cells as a therapeutic target. Moreover, the book presents novel perspectives that can pave the way for the development of innovative cancer treatment strategies.
Zhu Zeng respectively received his BE and PhD degree in Gui Zhou University and Peking University, Health Science Center, China. He worked as bioengineering postdoctor in the University of California, San Diego. He is current working as professor at the School of Biology and Engineering, Guizhou Medical University. His research work is focusing on the bioengineering, biomechanics, biomaterial, and tumor immunology.
Chapter 1 Introduction.- Chapter 2 The Measurement Protocols for Cell's Biophysical Characteristics.- Chapter 3 Bioinformatics analysis of the tumor microenvironment and mathematical modeling of the initiation of the dendritic cell-induced T-cell immune response.- Chapter 4 Relationship among the biophysical characteristics, cytoskeletal structure and functions of dendritic cells at different stages of differentiation.- Chapter 5 Effects of chemical factors in the tumor microenvironment on the biophysical properties and immune function of dendritic cells.- Chapter 6 Mechano-immunological coupling mechanism in DCs sensing mechanical stimulation in the microenvironment.- Chapter 7 Effects of selenium on DCs in the tumor microenvironment.
