This revised text considers the relation of biochemistry to other disciplines such as anatomy, physiology and pharmacology in the medical course. It furthers the application of biochemical concepts to the microcellular and subcellular structures of the cell and, more importantly, to the functioning of the body as a whole and disease processes. The chapter on the functions of the nucleus, mitochondria and the endoplasmic reticulum have been reorganized to account for the increased understanding of the roles of these organelles. There is also new emphasis given to the biochemistry of environmental hazards which includes a treatment of viral carcinogenesis. There is also a discussion of the results of recombinant DNA technology in the diagnosis of genetic disorders. In addition to providing guidance for students, the approach taken in this book will also be useful for teachers seeking an understanding of the role of biochemical principles which are valuable in medicine.
Auflage
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für höhere Schule und Studium
Editions-Typ
Illustrationen
549 b&w line drawings, index 23 b/w half tones
Maße
Höhe: 246 mm
Breite: 189 mm
ISBN-13
978-0-7236-0914-8 (9780723609148)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Part 1 Biochemistry of the cell and its metabolism: ultrastructure of the mammalian cell; roles of extracellular and intracellular membranes - membrane structure and membrane transport; role of subcellular organelles - lysosomes; peroxisomes; metabolism in the cytosol; mitochondria and energy conservation; inter-relationships of the mitochondria and cytosol; the nucleus; the endoplasmic reticulum. Part 2 Whole body metabolism: nutrition - general aspects - energy requirements and the supply of energy by oxidation of foodstuffs - proteins in the diet - dietary fats - vitamins - inorganic constituents of the diet; digestion and absorption of foodstuffs; hormones - a summary of their structures and functions; plasma glucose and its regulation; plasma lipids and their regulation; plasma amino acids and utilization of amino acids by the tissues; plasma electrolytes; plasma calcium and phosphate - regulation by Vitamin D and parathyroid hormone; starvation. Part 3 Specialized metabolism of tissues: blood - erythropoiesis - role of folate and vitamin B12 - metabolism in the red blood cell - blood clotting - catabolism of haemoglobin - iron and iron metabolism; functions of the liver; the kidney; muscle; bone and collagen - calcification; the brain and the central nervous system; the eye. Part 4 Environmental hazards - detoxication: toxicology - general aspects; toxic metals; metabolism of xenobiotics - xenobiochemistry; alcohol - effects on metabolism; carcinogenesis. Part 5 Biochemical basis of diagnosis - disease and its treatment: biochemical diagnosis; an example of metabolic disturbance - obesity; biochemical genetics - inborn errors of metabolism; principles of chemotherapy. Apppendices: Commonly occuring mono- and disaccharides; polysaccharides - starch and glycogen; glycosaminoglycans (mucopolysaccharides) - proteoglycans; naturally occurring a-amino acids; lipid chemistry and classification; phospholipids; purine and pyrimidine bases; nucleosides - nucleotides; glycolysis; pentose phosphate pathway - outline of stages; citric acid cycle; b-oxidation of fatty acids in mitochondrium; biosynthesis of cholesterol; summary of amino acid metabolism; ornithine cycle - synthesis of urea; the genetic code; transfer of RNAs; steps in eukaryotic protein synthesis.
