Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.
Rezensionen / Stimmen
"...a good purchase for most neuroscience and neurology libraries." - Doody's Health Science Book Review Journal
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Für höhere Schule und Studium
Professional/practitioner
Illustrationen
Maße
Höhe: 241 mm
Breite: 160 mm
Dicke: 25 mm
Gewicht
ISBN-13
978-1-58829-199-8 (9781588291998)
DOI
10.1007/978-1-59259-896-0
Schweitzer Klassifikation
to Molecular Neurosurgery.- Ribosome-Inactivating Proteins.- Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin.- Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin.- 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System.- Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin.- Cortical Cholinergic Deafferentation Induces A? Deposition.- Chemical Dissection of Brain Glucoregulatory Circuitry.- Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin-Based Immunotoxin.- Saporin Conjugates and Pain.- The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness.- Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons.- B Fragment of Cholera Toxin Conjugated to Saporin.
