General Introduction 1.Photodynamic therapy 2.Cell Death Mechanisms 3.Aims and Strategies of the Study Materials and Methods 1.Materials and Antibodies 2.Methods Apoptotic and Anti-Apoptotic signaling pathways induced by PDT with Hypericin 1.PDT with hypericin induces apoptosis and necrosis 2.Role of MAPKs in hypericin-induced apoptosis 3.PDT-induced Bcl-2 phosphorylation is associated with growth arrest in the G2/M phase of the cell cycle BCL-2 overexpression reveals a caspase-dependent mechanism of PDT-induced cytochrome C release 1.Introduction 2.Results 3.Discussion and Conclusions Summary and perspectives Samenvatting References
