The gastrointestinal tract is one of the major target organs in HIV infection and mucosal immunodeficiency caused by HIV might contribute to the frequently observed secondary infections and malignancies in AIDS. This special issue brings together the expertise of key scientists actively working in the field, who cover the most recent findings and highlight areas for future research. First, the importance of different lymphoid compartments in HIV infection and immune responses against HIV at mucosal sites are discussed. Entry of HIV into the mucosa and the pathogenesis of mucosal HIV infection and immunodeficiency are then considered, followed by data on the mechanisms of mucosal pathology. Finally, mucosal vaccination strategies and the effects of antiretroviral therapy on mucosal HIV infection are covered. Structured to give the reader broad information on recent advances without theneed to refer to complex immunological literature, this publication offers a valuable reference to the state of the art in this field. It is therefore recommended not only to mucosal immunologists but also to students and scientists involved in other areas of HIV research.
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
Maße
Gewicht
ISBN-13
978-3-8055-6739-8 (9783805567398)
Schweitzer Klassifikation
Part 1 Immune responses against HIV at mucosal sites: session summary; interpreting data in lymphocyte subsets in the blood of HIV patients - organ distribution, proliferation and migration kinetics are critical factors; analysis of virologic and immunologic events in HIV infection; chemoattractant factors and the control of human immunodeficiency virus replication; secretory immunity in HIV infection. Part 2 Pathogenesis of mucosal HIV infection and immunodeficiency: session summary; M cells as protals of entry of HIV; mucosal HIV infection; mucosal immunodeficiency in HIV/SIV infection. Part 3 Mechanisms of mucosal pathology in HIV infection: session summary; gastrointestinal pathology in rhesus monkeys with experimental SIV infection; nonmalabsorptive mechanisms of diarrhea in HIV infection. Part 4 Mucosal HIV infection - vaccination and therapy: delivery systems and adjuvants for vaccination against HIV; induction and expression of intestinal humoral immunity in HIV-infected individuals - prospects for vaccination against secondary enteric infections; intestinal disease associated with HIV infection - characterization and response to antiretroviral therapy.
