The chemistry of metals is providing new insights into DNA chemistry, making it necessary for scientists in this emerging interdisciplinary research to be able to understand work in both fields. This new volume provides an examination of the application of metal chemistry to molecular biology, as well as a review of recent research results. Its 11 chapters provide broad coverage of such topics as the development and use of metal complexes as tools in molecular biology, the involvement of metal ions in genetic regulation, and the importance of metal-based drugs in the treatment of cancer.
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ISBN-13
978-0-8412-1660-0 (9780841216600)
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Schweitzer Klassifikation
Metals and Molecular Biology; Chemical Nuclease Activity of 1,10-Phenanthrolinecopper: A New Reagent for Molecular Biology; Excited-State Modalities for Studying the Binding of Copper Phenanthrolines to DNA; Interaction of Porphyrins and Metalloporphyrins with Nucleic Acids; Porphyrins as Probes of DNA Structure and Drug-DNA Interactions; Searching for Metal-Binding Domains; Inorganic Reagents as Probes for the Mechanism of a Metal-Responsive Genetic Switch; The Fur Regulon of Escherichia coli K-12; 'NMR Spectroscopic Investigations: Pt Anticancer Drug Binding to Oligonucleotide Models of DNA; Base-Selective DNA Cleavage with a Cyclometalated Palladium Complex; Metal-Nucleotide Interactions
