Regeneration- Holy grail of Endodontics

Endodontic therapy has shown a high rate of success in the retention of teeth, in cases where even teeth are not restorable. The reasons for failure are apical resorption, fractures, incompletely formed roots or carious destruction, in addition vital pulp therapy is also not always predictable. Therefore, to regain the natural healthy tissue in order to replace the individual's lost or damaged tissue the concept of tissue engineering has been considered as the -GOLD STANDARD. Over the past century, endodontic therapy has shown a high rate of success in retention of teeth; however, many teeth are not restorable due to various reasons like apical resorption, fractures, incompletely formed roots or carious destruction and also vital pulp therapy is not always predictable.Recently, there has been an increasing interest in applying the concept of tissueengineering to endodontics. Many of the concepts in regenerative endodontics emerge from this burgeoning field of tissue engineering which emphasizes on the spatial assembly of distinctive stem cells, growth factors/ Morphogens and scaffolds to form a functional tissue or organ.