Due to the combined approach of molecular biology and physiology, knowledge of the mechanisms underlying the aetiology of many renal tubular disorders has seen important advances in recent years. The publication at hand provides a succinct and readable overview of the progress made in the understanding of transepithelial sodium transport and transcellular water transport, as well as discussing the essential role of the cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial electrolyte transport. Moreover, novel insights into renal calcium transport gained from an analysis of channels and the likely roles of the recently discovered family of renal voltage-gated chloride channels are reviewed, together with the molecular characteristics of phosphate transporters and their roles in the regulation of this anion. Due to the multidisciplinary approach adopted, this publication will be a most welcome source of up-to-date information for nephrologists, endocrinologists, geneticists and physiologists alike; moreover, it also provides possible points for future research.
Sprache
Verlagsort
Zielgruppe
Illustrationen
Maße
Gewicht
ISBN-13
978-3-8055-7143-2 (9783805571432)
Schweitzer Klassifikation
Disorders of the epithelial Na+ channel in Liddle's syndrome and autosomal recessive pseudohypoaldosteronism type 1 - Oh Y.S., Warnock D.G.; defective processing and trafficking of water channels in nephrogenic diabetes insipidus - Kamsteeg E.J., Deen P.M.T., van Os C.H.; defects in processing and trafficking of cystic fibrosis transmembrane conductance regulator - Kunzelmann K., Nitschke R.; mechanisms of renal calcium transport - Friedman P.A.; molecular pathology of renal chloride channels in Dent's disease and Bartter's syndrome - Thakker R.V.; severely impaired urine-concentrating ability in mice lacking the CLC-K1 chloride channel - Uchida S., Marumo F.; molecular characteristics of phosphate transporters and their regulation - Hernando N., Forster I.C., Biber J. Murer, H.
