Molecular Mechanisms to Regulate the Activities of Insulin-like Growth Factors

A. From Sulphation Factor to IGF-1, 40 Years of Research on the Regulation of Cartilage Growth (W.H. Daughaday). B. Diabetes and the Heart: Physiological and Therapeutic Aspects of IGF-1 (E.R. Froesch et al. ). C. Regulation of Gene Expression and Synthesis of IGF and IGFBP. Methods to analyze tissue-specific promoters for IGF and IGFBP gene expression (C.T. Roberts). Involvement of AP-1-like motifs in the IGF-1 gene regulation (Y. Kajimoto et al. ). Insulin-like growth factor binding protein-1 gene activation in human endometrium (L. Tseng et al. ). Regulation of ALS gene expression by growth hormone (Y. Boisclair et al. ). Insulin-like growth factor gene targeting (W. Won, L. Powell-Braxton). Genetic disruption of IGF binding proteins (J.E. Pintar et al. ). Targeted mutations of insulin and IGF-1 receptors in mice (D. Accili et al. ). D. Regulation of IGFBP Action. Methods to detect and analyze modified insulin-like growth factor binding proteins (S.M. Firth). IGFBP proteases - physiology/pathophysiology (J.M.P. Holly et al. ). Proteolytic fragments of IGF binding protein-3: physiological significance (M. Binoux et al. ). IGFBP regulation by proteases (C.A. Conover). Regulation of insulin-like growth factor I actions by insulin-like growth factor binding protein-5 (D.R. Clemmons et al. ). IGF-independent actions of IGFBPs (Y.Oh et al. ). The regulation and actions of ALS (P.J.D. Delhanty). E. Tissue-specific Regulation of IGF Activity. Insulin-like growth factors in the development of the pancreas ( D.J. Hill et al. ). The early embryonic neuroretina: a CNS site of production and action of (pro)insulin and IGF-1 (F. de Pablo et al. ). IGF-1 and uterine growth (O.O. Adesanya et al. ). Bone morphogenetic proteins and IGF systems (S. Mohan, D.J. Baylink). Regulation of IGF and IGFBP gene expression in bone (R. Okazaki). The IGF system in the ovary (G.F. Erikson et al. ). The roles of IGFs and IGFBP-1 in non-pregnant human endometrium and at the maternal: placental interface during human pregnancy (L.C. Giudice). The prostatic IGF system: new levels of complexity (A. Grimberg et al. ). Evolutionary aspects of the IGF system (C. Collet et al. ). The IGF system in the brain - response to injury and therapeutic potential (P.D. Gluckman et al. ). The IGF-1 paradox in cerebellar granule cells: prevention of death via apoptosis opens the route to death via glutamate-triggered necrosis (P. Calissano et al. ). IGFs and IGFBPs in organogenesis: development of normal and abnormal kidneys (V.K.M. Han, D.G. Matsell). Expression of IGF-1 and IGFBPs in rat kidney and the effect of GH and nutrition (S. Kobayashi, H. Nogami). Regulatory role of interleukin 1beta and nitric oxide on vascular smooth muscle cell proliferation in primary culture (T. Bourcier, A. Hassid). F. IGF Signal Transduction. The yeast two-hybrid system to investigate IGF-1 receptor signal transduction (R.W. Furlanetto et al. ).