This comprehensive compilation, written by an authoritative team of international contributors, surveys the role of Escherichia coli in health and disease. The potential of E. coli as a pathogen has increasingly been recognised in recent years and its mechanisms of virulence have been extensively investigated. This most valuable and timely account brings the subject fully up to date. First the diseases due to E. coli in man and animals are described in general terms and the part it plays in the normal flora. Then chapters are devoted to each of the recognised virulence factors and mechanisms, including capsules, adhesins, haemolysins, endotoxins and exotoxins, iron scavenging. The third section deals in detail with various diseases and their mechanisms. Finally, the host responses to infection are considered and the design of vaccines. This book will be of value to all scientists and clinicians with an interest in microbial pathogenicity.
Rezensionen / Stimmen
'... an impressive testament to sustained research into the fundamental molecular and biochemical nature of this organism ... There is much scope to project such information into clinical practice and this book will be an invaluable source for those engaged in research into this important pathogen'. Journal of the Royal Society of Medicine 'As a topical and thorough compendium of an ever growing field I commend this volume wholeheartedly.' Society for General Microbiology Quarterly 'The reader cannot fail to be stimulated ... The book ... can be recommended as a clear and competant contribution to a very important field of study.' The Lancet '... this volume will be most valuable'. Michael S. Donnenberg, Trends in Microbiology ' ... well presented and very readable'. Journal of Applied Bacteriology
Sprache
Verlagsort
Zielgruppe
Illustrationen
49 Tables, unspecified; 8 Halftones, unspecified; 32 Line drawings, unspecified
Maße
Höhe: 236 mm
Breite: 156 mm
Dicke: 37 mm
Gewicht
ISBN-13
978-0-521-45361-5 (9780521453615)
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Schweitzer Klassifikation
Foreword; Preface; Part I. Introduction; 1. Escherichia coli in human disease M. Sussman; 2. Escherichia coli infections in farm animal C. Wray and M. J. Woodward; 3. Escherichia coli in the normal flora of man and animals K. A. Bettelheim; Part II. Virulence Factors; 4. Capsules of Escherichia coli K. Jann and B. Jann; 5. Escherichia coli lipopolysaccharide in pathogenesis and virulence S. Hull; 6. Type 1 fimbriae of Escherichia coli S. N. Abraham and S. Jaiswal; 7. Fimbriae of enterotoxigenic Escherichia coli F. K. de Graaf and W. Gaastra; 8. Assembly of adhesive virulence-associated fimbriae in Gram-negative bacteria K. W. Dodson, F. Jacob-Dubuisson, R. T. Striker, S. J. Hultgren; 9. Heat-labile and heat-stable enterotoxins Y. Takeda; 10. Vero cytotoxins S. M. Scotland and H. R. Smith; 11. Haemolysins of Escherichia coli A. Ludwig and W. Goebel; 12. Iron and the virulence of Escherichia coli E. Griffiths; 13. Co-ordinate regulation of virulence gene expression in Escherichia coli C. J. Dorman and N. Ni Bhriain; Part III. Mechanisms of disease; 14. Enteropathogenic Escherichia coli P. H. Williams, T. J. Baldwin and S. Knutton; 15. Vero cytotoxin-producing Escherichia coli G.A. Willshaw, S. M. Scotland and B. Rowe; 16. Enteroinvasive Escherichia coli T. L. Hale, P. Echeverria and J. P. Nataro; 17. Soft tissue infection and septicaemia D. M. MacLaren; 18. Urinary tract infection J. R. Johnson; Part IV. Responses to infection; 19. Cell activation by uropathogenic Escherichia coli R. Steadman and N. Topley; 20. Immune responses to Escherichia coli J. W. Gray; 21. Vaccines against enterotoxigenic Escherichia coli A.-M. Svennerholm and J. Holmgren; Index.
