The Chemistry of Hyperpolarized Magnetic Resonance Probes, Volume Seven focuses on the chemical aspects of hyperpolarized NMR/MRI technology, with synthesis and characterizations of labeled compounds discussed from a practical point-of-view. A brief overview of the various hyperpolarization techniques are given, with the optimization of hyperpolarization conditions and the determination of critical parameters such as polarization level and T1 relaxation values described. A practical guide on the in vivo applications of hyperpolarized compounds in small animals is also included.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Produkt-Hinweis
Broschur/Paperback
Klebebindung
Maße
Höhe: 276 mm
Breite: 216 mm
Gewicht
ISBN-13
978-0-323-91842-8 (9780323918428)
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Schweitzer Klassifikation
Dr. Suh is an assistant professor with the college of pharmacy, University of North Texas Health Science Centre. She received her Ph.D. in Biomedical Engineering from UT Southwestern. She is interested in developing 13C, 15N-labeled compound as hyperpolarized MR probe that can be used as a tracer in in vivo real time metabolism study. She has been working with Dr. Park to investigate branched-chain amino acids metabolism in glioma. Zoltan Kovacs, Ph.D., UT Southwestern specializes in the design and synthesis of novel agents for magnetic resonance imaging and radiopharmaceutical applications.
One major current emphasis of Dr. Kovacs' work is generating hyperpolarized compounds for magnetic resonance spectroscopy (MRS) and imaging (MRI) of nuclei other than 1H. Conventional MRI is not well suited for imaging nuclei other than proton because of the inherently low sensitivity of NMR. The technology of supercharging the nuclear spin of molecules, called dynamic nuclear polarization (DNP) can dramatically increase the sensitivity of MRS and MRI analysis.
Dr. Kovacs is designing hyperpolarized 13C-labeled compounds that can be used as tracers to analyze the flux of molecules through metabolic pathways in healthy and diseased tissues. While 13C labeled substrates can directly enter the metabolic processes, their application is limited by rapid loss of spin polarization, called T1 relaxation, ranging from few seconds to a couple of minutes. Dr. Kovacs is developing tracer molecules based on the nonradioactive isotope 89Y and other low gamma nuclei such as 107.109Ag, which can have relaxation times of up to several minutes. Dr. Kovacs is developing various hyperpolarized 89Y-containing complexes that could be used to measure physiological parameters such as pH, temperature, and the oxidation/reduction state of molecules.
Herausgeber*in
Assistant Professor, University of North Texas Health Science Centre (UNTHSC), Dallas, TX, USA
Associate Professor, Advanced Imaging Research Center, University of Texas Southwestern (UTSW), Dallas, TX, USA
1. Hyperpolarized tracer design, synthesis and characterization
2. Optimization of hyperpolarized NMR signals in dissolution dynamic nuclear polarization
3. The chemistry of parahydrogen induced polarization (PHIP)
4. Beyond 13C-pyruvate: Biomedical applications with alternate hyperpolarized probes
5. Technical Considerations of MRI methods for validating DNP probes in small animals
