Part 1 Long-term potentiation: long-term potentiation (LTP) and depression (LTD) in the neocortex and hippocampus - an overview, L.Bindmann et al; persistance of hippocapal long-term potentiation - regulation by protein kinase C, P.A.Colley. Part 2 Galanin: galanin - localization, release and putative functions, W.D.Hutchison and C.R.Morton; brain galanin receptors - anatomical localization and possible functional role, C.Kohler and V.Chan-Palay; electrophysiological studies of the actions of galanin in the CNS, P.Dutar et al; galanin - distribution and function, A.Dresse and V.Seutin. Part 3 Opioids: opioid receptors, S.J.Paterson; type selective receptor and post-receptor regulation in the opioid system - studies with neuronal cultures, R.Simantov; the pathophysiological functions of Beta-casomorphins, K.Ramabadran et al; opioids and memory, I.Izquierdo; opioid induced respiratory depression in the management of acute pain - clinical aspects, A.N.Sandler. Part 4 Autonomic transmission: neural regulation of vascular tone, J.A.Bevan; role and pharmacology of vascular pre - and post-junctional alpha2-adrenoceptors, J.R.Docherty and S.Connaughton; synaptic transmission in airways, P.J.Barnes; nitric oxide as a neurotransmitter in smooth muscle, W.Martin et al. Part 5 5-Hydroxytryptamine (5HT): physiological and pharmacological aspects of 5HT3 receptor function, J.A.Peters et al; presynaptic effects of 5HT, M.Gothert; electrophysiological effects of 5HT on vertebrate motoneurones, O.Kiehn; vascular 5HT receptors, A.H.Bom and P.R.Saxena; CNS effects of stimulating 5HT receptor subtypes, R.Samanin.