The pursuit of a definition for severe and persistent mental illness; medical problems of the seriously and persistently mentally ill; new medications - major psychopharmacologic advances; a systematic psychopharmacologic approach to the drug-resistant chronic mentally ill patient; the family - advancing the alliance; coerced community treatment and psychiatric hospital recidivism; clinical case management for the seriously mentally ill; when the chronically mentally ill patients grows old; dual diagnosis - serious mental illness and substance abuse; homelessness, serious mental illness and outreach; assertive community treatment; financing the care for the seriously mentally ill; legal issues - competency, criminality and care; self help groups serving the seriously mentally ill; quality improvement and serious mental illness.