Abbreviations; Foreward; Methods for studying metabolism and distribution in vivo of radiolabelled drugs; Liver perfusion techniques in toxicology; Preparation and culture of mammalian cells; Post-implantation embryo culture for studies of teratogenesis; The identification and assessment of covalent binding in vitro and in vivo; Evaluation of lipid peroxidation in lipids and biological membranes; Preparation and use of renal and intestinal plasma membrane vesicles for toxicological studies; Preparation and characterisation of microsomal fractions for studies of xenobiotic metabolism; Preparation and use of mitochondria in toxicological research; Preparation and use of lysosomes and peroxisomes in toxicological research; Index