Supercritical Fluid Chromatography

The RSC Chromatography Monographs Series is designed for the individual practising chromatographer, providing guidance and advice on a wide range of chromatographic techniques with the emphasis on important practical aspects of the subject. Both established and developing areas of chromatography will be covered, including GLC, HPLC, and TLC plus the newer areas such as SFC, affinity chromatography, and counter-current chromatography. Focussing on a specific topic within chromatography, each monograph will provide a concise, up-to-date guide for day-to-day use in the analytical laboratory.


Supercritical Fluid Chromatography (SFC) is the first title in this important series. As an analytical or preparative technique, SFC offers an alternative separation selectivity and different sampling requirements to the older established methods of GLC and HPLC. SFC promises to revolutionize analytical procedures in the food, petroleum, and pharmaceutical industries and this publication provides practising chromatographers in both industry and academia with a perspective on its principles, practice, and potential applications.


Written by a team of acknowledged experts in the field, this book discusses the origins and development of SFC, the instrumentation that has been used and the growth of the technique from the related methodologies of GLC and HPLC.


It also covers in great detail the ways in which the separations in SFC can be altered to increase selectivity, compares the roles of packed and capillary columns, and covers the coupling of SFC to mass spectrometry. An invaluable guide for all scientists from government, industry and academia, with an interest in SFC.