Some historical insights; acute or single dose toxicity; limitations and uses of the ED50 or LD50; inhalation toxicity and the concept of chronicity; subchronic and chronic toxicity testing; absorption, distribution and excretion of chemicals (Roebuck); biotransformation of chemicals; food and pesticide laws, setting tolerances; survey of pesticides; the rise and fall of DDT; chlorines, benzenes rings and dioxins; heavy metals (Roebuck); the sulfur cycle and reducing type air pollution; the nitrogen cycle and oxidizing type air pollution; the detergent controversy (Gosselin); (irradiation of foods versus radon); (the Goldfine hypothesis) (Kaplita); (toxic waste dumps) (Devlin); the alcohols; carcinogenicity, mutagenicity, teratogenicity.
