Virtually all the chapters have been rewritten for this edition, many by new, internationally recognized contributors. This text is a reference and textbook on basic neurochemistry. Highlights include: all-new accounts of olfaction and taste, glutamate and aspartate, GABA, glycine, purinergic transmitter systems, neuropeptides, G-proteins and cyclic nucleotides in the nervous system, molecular targets of abused drugs, neurotransmitter uptake systems, neurotoxicity, and fluid and solute regulation; revised and strategically expanded coverage of histamine and serotonin; significantly expanded coverage of neurotransmitters, receptor families, and second messenger systems; timely updates on molecular genetic approaches to inherited neurological degenerative disorders and mitochondrial diseases; extensive references to the current literature including citations of 1993 publications.
Auflage
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Editions-Typ
Illustrationen
99 halftones, 238 illustrations, 77 tables, references
Maße
Höhe: 254 mm
Breite: 178 mm
Gewicht
ISBN-13
978-0-7817-0104-4 (9780781701044)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Part 1 Neural membranes: neurocellular anatomy; cell membrane structure and functions; membrane transport; electrical excitability and ion channels; lipids; myelin formation, structure and biochemistry; molecular biology of vision; olfaction and taste in vertebrates - molecular and organizational strategies underlying perception. Part 2 Synaptic function: chemically mediated synaptic transmission - an overview; receptors and signal transduction - classification and quantitation; acetylcholine; catecholamines; serotonin; histamine; opioid peptides and opioid receptors; neuropeptides; excitatory amino acid transmitters; GABA and glycine; purinergic systems; phosphoinositides; G-proteins and cyclic nucleotides in the nervous system; protein phosphorylation and the regulation of neuronal function; eicosanoids. Part 3 Molecular neurobiology: gene expression in the mammalian nervous system; molecular probes for gene expression; molecular genetic approaches to inherited neurological. Part 4 Cellular neurochemistry: degenerative disorders; axonal transport and the neuronal cytoskeleton; development of the nervous system; neural plasticity and regeneration; biochemistry of aging in the mammaliam brain; circulation and energy metabolism of the brain; blood-brain-cerebrospinal fluid barrier. Part 5 Medical neurochemistry: the muscle fibre and disorders of muscle excitability; diseases of carbohydrate, fatty acid, and mitochondrial metabolism; vitamin and nutritional deficiencies; biochemistry of neuropathy; diseases involving myelin; genetic disorders of lipid, glycoprotein, and mucopolysaccharide metabolism; disorders of amino acid metabolism; metabolic encephalopathies and coma; molecular targets of abused drugs; ischemia and hypoxia; epileptic seizures; neurotransmitters and disorders of the basal ganglia; biochemistry of Alzheimer's disease; positron emission tomography. Part 6 Behavioural neurochemistry: biochemical aspects of the psychotic disorders; biochemical hypotheses of mood and anxiety; endocrine effects on the brain and their relationships to behaviour; learning and memory.
