The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy.
* The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated
* The first two sections cover the background to, and principles of, treatment in different clinical situations
* Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects
* Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach
* This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries
Auflage
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Maße
Höhe: 27.9 cm
Breite: 21.6 cm
Dicke: 4.6 cm
Gewicht
ISBN-13
978-1-118-93700-6 (9781118937006)
Schweitzer Klassifikation
Simon Shorvon MA MB BChir MD FRCP
Professor in Clinical Neurology and Clinical SubDean, UCL Institute of Neurology, University College London and Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Emilio Perucca MD PhD FRCP(Edin)
Professor of Medical Pharmacology, Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; and Director, Clinical Trial Center, C Mondino National Neurological Institute, Pavia, Italy
Jerome Engel Jr MD PhD
Director, Seizure Disorder Center, Jonathan Sinay Distinguished Professor, Neurology, Neurobiology, Psychiatry and Behavioural Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Herausgeber*in
Institute of Neurology, University College London
University of Pavia, Italy
University of California at Los Angeles, USA
List of Contributors
Preface to the Fourth Edition
Preface to the First Edition
Historical Introduction: The Drug Treatment of Epilepsy from 1857 to 2015
Simon Shorvon
Section I ? Introduction (Lead editor: Simon Shorvon)
1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE 1
Simon Shorvon
2 Differential Diagnosis of Epilepsy 24
Mark Cook
3 Mechanisms of Epileptogenesis 38
Giuliano Avanzini and Silvana Franceschetti
4 Antiepileptic Drug Discovery 52
H. Steve White and Melissa Barker-Haliski
5 Antiepileptic Drug Development 61
Dieter Schmidt
6 Mechanisms of Antiepileptic Drug Action 75
Matthew C. Walker and Rainer Surges
7 Mechanisms of Drug Resistance and Tolerance 92
Wolfgang Loescher and Dieter Schmidt
8 Epilepsy Biomarkers 103
Jerome Engel, Jr. and Asla Pitkaenen
Section II ? Principles of Medical Management (Lead editor: Simon Shorvon)
9 General Principles of Medical Management 110
Emilio Perucca
10 Pharmacokinetic Optimization of Therapy 124
Svein I. Johannessen, Cecilie Johannessen Landmark and Emilio Perucca
11 Management of Chronic Active Epilepsy in Adults 139
Simon Shorvon
12 Management of Epilepsy in Remission 148
Patrick Kwan, Howan Leung and Xiaoting Hao
13 Management of Epilepsy in Neonates and Infants 156
Elissa G. Yozawitz and Solomon L. Moshe
14 Management of Childhood Epilepsy Syndromes 174
Colin D. Ferrie
15 Management of Epilepsy in People with Intellectual Disabilities 193
Eylert Brodtkorb
16 Management of Epilepsy in the Elderly 205
Hiba Arif Haider and Lawrence J. Hirsch
17 Emergency Treatment of Seizures and Status Epilepticus 221
Matthew C. Walker and Simon Shorvon
18 Management of Medical Comorbidity Associated with Epilepsy 245
Gagandeep Singh
19 Psychiatric Features of Epilepsy and their Management 259
Brent Elliott and Simon Shorvon
20 Prevention and Management of Side-effects of Antiepileptic Drugs 275
Gaetano Zaccara and Piero Perucca
21 Ketogenic Diets 288
Eric H. Kossoff and Courtney A. Haney
22 Complementary and Alternative Treatments for Epilepsy 298
Sallie Baxendale
23 Reproductive Aspects of Epilepsy Treatment 311
Torbjoern Tomson
24 Genetic Counselling in Epilepsy 323
Federico Zara
25 Drug Interactions 344
Edoardo Spina and Domenico Italiano
26 Medical Treatment of Epilepsy in Resource-Poor Countries 360
Patrick Adjei
Section III ? Antiepileptic Drugs (Lead editor: Emilio Perucca)
27 Introduction to the Choice of Antiepileptic Drugs 365
Emilio Perucca
28 Acetazolamide 376
Miri Y. Neufeld
29 Adrenocorticotropic Hormone and Corticosteroids 388
Federico Vigevano and Maria Roberta Cilio
30 Benzodiazepines Used in the Treatment of Epilepsy 398
Eugen Trinka and Francesco Brigo
31 Brivaracetam 418
Joseph D?Souza and Emilio Perucca
32 Carbamazepine 431
Torbjoern Tomson and Svein I. Johannessen
33 Eslicarbazepine Acetate 447
Meir Bialer and Christian Elger
34 Ethosuximide 460
Tracy A. Glauser and Emilio Perucca
35 Felbamate 472
Ilo E. Leppik and James R. White
36 Gabapentin 479
Ernest R. Somerville, Andrew W. Michell and Arjune Sen
37 Lacosamide 489
Rajesh Sachdeo and Roopal Karia
38 Lamotrigine 498
Awais Riaz and Fumisuke Matsuo
39 Levetiracetam 516
Derek J. Chong and Jacqueline A. French
40 Oxcarbazepine 533
Edward Faught and Hyunmi Kim
41 Perampanel 546
Martin Brodie
42 Phenobarbital, Primidone and Other Barbiturates 555
Roberto Michelucci and Elena Pasini
43 Phenytoin 574
Mervyn J. Eadie
44 Piracetam 589
Simon D. Shorvon
45 Pregabalin 595
Sylvain Rheims and Philippe Ryvlin
46 Retigabine 606
Michel Baulac
47 Rufinamide 617
Victor Biton
48 Stiripentol 628
Tapani Keraenen
49 Tiagabine 633
Reetta Kaelviaeinen
50 Topiramate 642
J. Helen Cross and Catherine J. Riney
51 Valproate 652
Anthony G. Marson and Graeme J. Sills
52 Vigabatrin 667
Guenter Kraemer and Gabriele Ch. Wohlrab
53 Zonisamide 680
Michel Baulac
54 Other Less Commonly Used Antiepileptic Drugs 689
Martin Holtkamp
55 Drugs in Clinical Development 701
Norman Delanty and H. Steve White
Section IV ? Presurgical Assessment and Epilepsy Surgery (Lead editor: Jerome Engel, Jr.)
56 Overview of Surgical Treatment for Epilepsy 709
Jerome Engel, Jr.
57 Scalp EEG in the Epilepsy Surgery Evaluation 723
Christine B. Baca and John M. Stern
58 Invasive EEG in Presurgical Evaluation of Epilepsy 733
Dennis Spencer, Dang K. Nguyen and Adithya Sivaraju
59 MEG in Epilepsy Surgery Evaluation 756
Hermann Stefan and Paul Boon
60 MRI in Presurgical Evaluation 764
Christian E. Elger and Bernd Weber
61 PET and SPECT in Presurgical Evaluation of Epilepsy 775
Karolien Goffin and Wim Van Paesschen
62 Special Neurophysiological Techniques 787
Francois Mauguiere and Julien Jung
63 Neuropsychological Testing in Presurgical Evaluation 804
Marilyn Jones-Gotman and Gail L. Risse
64 Presurgical Psychiatric Evaluation 817
Andres M. Kanner
65 Mesial Temporal Lobe Surgery and Other Lobar Resections 829
James Leiphart and Itzhak Fried
66 Resective Surgery of Neoplasms 842
Nicholas M. Wetjen and Gregory D. Cascino
67 Resective Surgery of Vascular and Infective Lesions for Epilepsy 858
Christopher E. Uff and Neil D. Kitchen
68 Surgery of Developmental Anomalies Causing Epilepsy 878
Ahyuda Oh, Joshua J. Chern and Youssef G. Comair
69 Hemispheric Operations for Epilepsy 887
Georg Dorfmueller, Christine Bulteau and Olivier Delalande
70 Corpus Callosum Operations 895
David W. Roberts
71 Hypothalamic Hamartoma 903
John F. Kerrigan
72 Multiple Subpial Transection 916
Adriana Bermeo-Ovalle and Michael C. Smith
73 Awake Surgery for Epilepsy 922
Webster H. Pilcher
74 Epilepsy Surgery in Children 931
Jason S. Hauptman and Gary W. Mathern
75 Complications of Epilepsy Surgery 941
Charles E. Polkey
76 Anaesthesia for Epilepsy Surgery 952
Barbara M. Van de Wiele
77 Vagus and Trigeminal Nerve Stimulation 959
Steven C. Schachter
78 Brain Stimulation for Epilepsy 967
Gregory K. Bergey and Robert S. Fisher
79 Non-Resective Approaches for Medically Intractable Epilepsy 980
Thomas J. Gianaris, Andrea G. Scherer and Nicholas M. Barbaro
80 Future Focal Treatment Approaches to Epilepsy 987
Laura Mantoan Ritter and Hannah Cock
81 Epilepsy Surgery in Countries with Limited Resources 999
Andre Palmini and Kurupath Radhakrishnan
Index 1008
