Insulin structure and insulin action. Bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake (K. Drejer, U. Ribel, V. Kruse, A.R. Sorensen, I. Jensen and S. Gammeltoft). Mutant insulin receptors. Insulin resistance by unprocessed insulin proreceptors due to point mutation at the cleavage site (M. Kobayashi, T. Sasaoka, M. Sugibayashi and Y. Shigeta). Genetic defect of T-subunit of insulin receptors (H. Makino, M. Taira, F. Shimada, N. Hashimoto, Y. Shimada, O. Nozaki and S. Yoshida). Signal transduction in insulin action. Evidence for insulin-dependent activation of serine kinase activity via tyrosine kinase activity of insulin receptors (Y. Tashiro-Hashimoto, R. Yamamoto-Honda, K. Momomura, K. Tobe, Y. Akanuma and M. Kasuga). The structure and regulation of the insulin-activated S6 (SER/THR) protein kinases: Signalling intermediates in insulin action (J. Avruch, D.J. Price, P. Banerjee, M.F. Ahmad, J.R. Grove, N. Mukhopadhyay, A. Balasubramanyam and J.M. Kyriakis). Insulin action in NIDDM and ageing. Insulin action and insulin resistance in non-insulin dependent diabetes mellitus (J.M. Olefsky). Changes in insulin action with ageing in rats (H. Kuzuya, H. Nishimura, S. Kono, A. Kosaki, G. Inoue, M. Okamoto and M. Okamoto). Mechanism of glucose transport. Glucose transporter -structure and function (Y. Oka and T. Asano). Insulin activated glucose transport, mechanistic questions (P.F. Pilch). Index of Authors.