Historical development of the concept of neuronal specificity; development of retinotectal projection in Xenopus; axon pathfinding and the formation of maps in the retinotectal system; in vitro investigations of fibre-fibre and fibre-glial cell interactions in the development of the amphibian visual system; NMDA receptors and intertectal plasticisty in Xenopus; plasticity of binocular visual connections in the frog - from R.M. Gaze to NMDA; experimental manipulation of the developing rodent visual system; refinement of topographic projections in the rodent, avian, amphibian and fish visual systems; pyramidal cell modules in rat visual cortex - their structure and development; architecture fo sensory fibre projections - implications for neuronal specificity in the spinal cord; the conditioned goldfish retinal explant as an experimental model of nerve regeneration; the morphology of developing and regenerating retinal ganglion cels; development of the anuran retina - past and present; activity-driven mechanisms for sharpening retinotopic projections - correlated activity, NMDA receptors, calcium entry and beyond; concerning the logic of growth and form in living systems; three glimpses of evolution; models for the formation of ordered retinotectal connections; neural specificity revisited.