Drug-Membrane Interactions

Preface. Foreword. INTRODUCTION Function, Composition, and Organization of Membranes OCTANOL--WATER PARTITION VERSUS PARTITIONING INTO MEMBRANES ANALYTICAL TOOLS FOR THE ANALYSIS AND QUANTIFICATION OF DRUG--MEMBRANE INTERACTIONS High--performance Liquid Chromatography (HPLC) Displacement of 45Ca from Phospholipid Head Groups Differential Scanning Calorimetry (DSC) Fluorescence Techniques Fourier Transform Infrared Spectroscopy (FT--IR) Electron Spin Resoncance (ESR) Small Angle Neutron and X--ray Diffraction Nuclear Magnetic Resonance (NMR) Circular Dichroism (CD) UV Spectroscopy DRUG--MEMBRANE INTERACTIONS AND PHARMACOKINETICS OF DRUGS Drug Transport Drug Distribution Uptake into and Distribution within Bacterial Cells Drug Accumulation, Toxicity, and Selectivity DRUG--MEMBRANE INTERACTIONS AND PHARMACODYNAMICS Drug Efficacy Drug Resistance COMPUTER SIMULATION OF PHOSPHOLIPIDS AND DRUG--PHOSPHOLIPID INTERACTIONS Modeling Strategies for Studying Phospholipids and Drug--Phospholipid Interactions Computer Simulations with Phospholipids Concluding Remarks INDEX