The book covers the principles and applications of the photodynamic therapy (PDT), a new promising platform for veterinarians, to treat intricate diseases like cancer and microbial infections. The therapy involves three combined fundamental elements: 1) the use of photosensitizer drugs; 2) light emitted by different sources and devices and 3) molecular oxygen. This association leads to microbial or cancer cells death obtained by oxidative stress.Antimicrobial PDT is a minimally invasive and cost-effective therapy, and due to its action mechanism, microbial resistance is not observed rendering it a huge differential when compared to antimicrobial drugs such as antibiotics. Antineoplastic PDT acts with high selectivity in cancer cells promoting their death with low adverse effects to the patient´s health and immune integrity.The book is pioneer in introducing this therapeutic modality for veterinarians. It addresses from basics to clinical practice showing the PDT history and fundamentals for non-experts and reporting a collection of basic and clinical studies about PDT in cancer and infections to ensure its safe use by practitioners. Illustrations are provided to give the reader examples of successful procedure in treating pets or other animals. Future perspectives and innovative applications involving nanotechnology and advanced drug delivery are also presented.Photodynamic therapy is an innovative and advanced tool for veterinarian practitioners, students and researchers looking for expanding their competence in Veterinary Medicine.
Auflage
Sprache
Verlagsort
Illustrationen
3
120 farbige Tabellen, 66 farbige Abbildungen, 3 s/w Abbildungen
Maße
Höhe: 235 mm
Breite: 155 mm
ISBN-13
978-3-319-45008-7 (9783319450087)
DOI
10.1007/978-3-319-45007-0
Schweitzer Klassifikation
FP Sellera received his DVM degree in Veterinary Medicine from the Universidade Metropolitana de Santos in 2010 and his MSc in Sciences from the University of São Paulo, where he is currently finishing his PhD research, in 2014. His main research interest is in Clinical Microbiology with an emphasis on Therapeutics. Since 2010 he has been working on antimicrobial photodynamic therapy in Veterinary Medicine as an alternative treatment approach for infections in animals. CL Nascimento graduated from the Rural Federal University of Rio de Janeiro with a degree in Veterinary Medicine in 1993 and received her MSc in Animal Surgery from São Paulo State University in Botucatu in 2014. She is currently head of the Veterinary Unit at Santos Aquarium, where she works on the clinical and surgical rehabilitation of aquatic and marine animals. Her research interests include the pathology and rehabilitation of wild and marine animals, animal surgery and photodynamic therapy. MS Ribeiro received her BSc degree in Physics from the University of Campinas in 1987 and her PhD in Sciences from the University of São Paulo in 2000. She is currently a Senior Researcher at the IPEN-CNEN/SP, where she works in the field of Biomedical Optics (Biophotonics) with a focus on optical therapy and nanomaterials. Her research interests include tissue optics, photobiomodulation and photodynamic therapy.
History of Photodynamic Therapy.- Photophysical and photochemical mechanisms.- Photosensitizers.- Molecular damage.- Cellular damage.- Systemic effects.- Multimodality dosimetry.- How to enter PDT in the clinical practice?.- Basic studies in cancer PDT.- Clinical applications of cancer PDT.- Basic studies in antimicrobial PDT.- Clinical applications of antimicrobial PDT.- Other practices in PDT.- Future perspectives.
