The advent of brain imaging techniques in the 1970s disclosed abnormalities in the subcortical white matter of a high number of elderly subjects. These changes appear increasingly relevant to motor cognitive impairment of the aging brain. A European task force studying age-related white matter changes has been set up with the aim of expanding knowledge, harmonizing definition criteria and increasing both clinical and experimental research. These proceedings are organized with the above purposes in mind. The focus is primarily on pathophysiology. Pathology data, the role of risk factors, relation of imaging to pathology and preliminary experimental evidence about the sensitivity of white matter to ischaemia are also presented and discussed.
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Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
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ISBN-13
978-3-8055-6721-3 (9783805567213)
Schweitzer Klassifikation
Pathophysiology mechanisms in the development of age-related white matter changes of the brain; neuropathology of white matter changes in Alzheimer's disease and vascular dementia; a review on blood pressure and ischaemic white matter lesions; experimental approaches to white matter disease; white matter changes and poststroke dementia; the overlap between Alzheimer's disease and vascular dementia - the role of white matter changes; propentofylline in the treatment of Alzheimer's disease and vascular dementia - a review of phase III trials; co-operation and networking on white matter disorders - the European Task Force on Age-Related White Matter Changes.
