Hormesis, Brain Aging and Metabolism: Volume 295

Cristoforo Scavone is a Principal Investigator at the Neuropharmacology Research Laboratory at the University of Sao Paulo (USP), Brazil, specializing in molecular biology and biochemistry with a focus on aging and related diseases. With a degree in Pharmacy and Biochemistry from the University of Sao Paulo (USP), a master's and PhD in Pharmacology from USP, and a Post-doctorate from the Massachusetts General Hospital - Harvard Medical School, Boston, USA. Associate Professor at USP (2003), Member of the Sao Paulo State Academy of Sciences (2012), PhD coordinator of the Department and of the Institute of Biomedical Science (2006-2012), and Head of the Department of Pharmacology (2013-2017) at USP. He is a Professor at the Department of Pharmacology of the Institute of Biomedical Sciences at USP (2009-) and a Research Fellow 1A from CNPq (National Council for Scientific and Technological Development). Contributed to the field of Pharmacology and Neuroscience with emphasis on neuroinflammation, Na, K-ATPase, and signaling cascade linked to aging, degenerative diseases, and neurological and neuropsychiatric disorders. He has explored changes in the signaling cascade in the brain and its correlation with peripheral diseases (chronic kidney disease, asthma, obesity) and chronic unpredictable stress linked to the inflammation process. Throughout his career, Scavone has introduced new knowledge in studies of adaptive responses associated with inflammatory messengers, hormesis, and cognition involving cardiotonic steroids, glucocorticoids, Klotho protein, and glutamate. As a member of the Brazilian Na, K-ATPse group, he has organized various Meetings in Brazilian institutions. These events are a pivotal platform for scientific discussions that significantly advance fundamental knowledge in Na, K-ATPase biochemistry, molecular biology, and related fields. This group has recently introduced new selective cardiotonic steroids (Benzylidene Digoxin) with a potential therapeutic effect in a rare neurological disorder (Alternating hemiplegia of childhood). He is a Member of the Editorial Board of PlosOne, Scientific Reports, British Journal of Pharmacology, Frontiers in Endocrinology, and Aging Neuroscience. With over 150 publications in PubMed, he has research projects funded by prestigious Brazilian agencies like FAPESP (The State of Sao Paulo Research Agency), CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), and FINEP (The Financier of Studies and Projects - Innovation and Research Program from Brazil Science and Technology Ministery). As a mentor to graduate students and postdocs, he has formed a new generation of professors and scientists in Brazil and foreign institutions, leading to improvement in research in the field of neuropharmacology and neuroscience.

Elisa Mitiko Kawamoto is associate professor and principal investigator of Laboratory of Molecular and Functional Neurobiology at Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo. specializing in neuropharmacology with a focus on the brain plasticity and non-pharmacological strategies against cognitive deficit. With a Ph.D. from University of Sao Paulo and postdoctoral training at National Institute on Aging, National Institutes of Health in Baltimore USA. I started my independent position ten years ago, since then I have been focused to investigate potential effects of non-pharmacological strategies for the treatment of brain diseases. One of my research interests is related to study the effects of calorie restriction or physical exercise to ameliorate cognitive deficits induced by diverse factors such as neuroinflammation, aging and neurological disorders. My contribution to this field is that intermittent fasting, physical exercise and intermittent fasting mimetics (phytochemicals) can ameliorate cognitive dysfunction induced by factors mentioned above. My laboratory has been looked for the effects of these strategies to boost chronic neuroinflammation which can cause deficit in learning and memory processes, impacting a normal brain function and it can be one of the underlying mechanisms of neurodegeneration involved in the pathogenesis of several brain diseases such as Alzheimer?s disease, amyotrophic lateral sclerosis, and others. I have been training undergraduate, master and PhD students and supervising postdoctoral trainees in my own laboratory which has been focused to study calorie restriction and physical exercise as non-pharmacological strategies. Besides, in this period I was granted with funds and fellowships (master, PhD and post-doctoral) from state and federal agency fundings. During this time my laboratory has been acquired more techniques, not only coming from my background trainings but also from collaborators inside the country and abroad.

Rosana Camarini is an Associate Professor and Principal Investigator at the Universidade de Sao Paulo, Brazil, specializing in neuropsychopharmacology with a focus on the neurobiological basis of drug addiction and dependence. With a Ph.D. from Universidade Federal de Sao Paulo and postdoctoral training at Ernest Gallo Clinic and Research Center, UCSF, her academic journey has been marked by a commitment to understanding the interplay between early drug exposure, environmental stimuli, and addictive behaviors, with focus on drug addiction. Additionally, she has served as a Visiting Professor at Medical University of South Carolina, Charleston, USA, Arizona State University, Tempe, USA, and Sorbonne Universite, Paris, France, enriching her academic experience and fostering international collaborations. Throughout her career, Camarini has explored the behavioral and neurochemical/molecular effects of alcohol and cocaine exposure during early drug exposure, particularly during prenatal and adolescent stages. Moreover, she has investigated the impact of environmental enrichment/exercise on addiction, highlighting its potential as a non-pharmacological intervention. Camarini served as President of the International Society for Biomedical Research on Alcoholism (ISBRA), from 2020-2022, where she spearheaded initiatives promoting diversity and early career development. Additionally, her role in revitalizing the Latin American Society for Biomedical Research on Alcoholism (LASBRA) underscores her dedication to regional scientific advancement. Camarini has chaired and given lectures at numerous international symposia, contributing to the global discussion on addiction research. In addition to her academic pursuits, Camarini holds key administrative roles, including Head of the Pharmacology Department and Coordinator of the Neuroscience Research Support Center at Universidade de Sao Paulo, Brazil (USP). Her commitment to scientific rigor is evident through her involvement in "Experimental Planning and Reproducibility Strategies Core? of the Institute of Biomedical Sciences at USP. With over 100 publications indexed in PubMed, she has a plethora of ongoing research projects funded by prestigious Brazilian agencies like FAPESP (The State of Sao Paulo Research Agency) and CNPq (National Council for Scientific and Technological Development). Camarini's contributions also extend to serving as an editor and editorial board member for addiction journals. Through her mentorship of graduate students and postdocs, she nurtures the next generation of scientists, ensuring a legacy of excellence in neuropsychopharmacology research.