Foreword - perspectives in understanding pancreatic islet growth, M. Krakowski and N. Sarvetnick; the physiological roles of prolactin, growth hormone and placental lactogen in the regulation of islet beta cell proliferation, T.C. Brelje and R.L. Sorenson; the role of cytokine receptor signalling in beta cell growth and function, J.H. Nielsen and N. Billestrup; growth and differentiation of the islet cells in neonates, G. Rosselin and S. Emami; PDX-I - an activator of genes involved in pancreatic development and islet gene expression, M. Peshavaria and R. Stein; balance between autoimmune destruction and regeneration - dual activities of IFN gamma in wound healing and inflammation, E.M. Jones and N. Sarvetnick; role of transforming growth factors alpha and beta in the normal and diseased pancreas, S.B. Koevary; partial pancreatectomy as a model of pancreatic regeneration, S. Bonner-Weir et al; developmental roles of cell adhesion molecules - implications for pancreatic islet morphogenesis, V. Cirulli and A. Hayek; neurotrophic factors - possible implication in beta cell development and regeneration, R. Scharfmann and P. Czernichow; determinants of pancreatic islet cell neogenesis - the cellophane wrap model, A.I. Vinik et al; development of the endocrine pancreas - lessons from studies of pluripotent islet cultures, O.D. Madsen et al; human pancreatic beta cell differentiation and growth in vitro and after transplantation, T. Otonkoski et al.