Current Concepts of a New Animal Model

List of Contributors. Preface. I. Breeding and Genetics. 1. Breeding of the NON mouse and its characteristics (S. Makino et al.). 2. Biological characteristics of the NOD mouse, a related strain of the NON mouse (M. Harada, S. Makino). 3. Analysis of the insulin genes in the NON mouse (S. Ohgaku, T. Sawa). II. The NON Mouse as an Animal Model for Type II Diabetes Mellitus. 4. Diabetic syndrome in the NON mouse (G. Hasegawa et al.). 5. Body fat accumulation and metabolic disturbance in the NON mouse (M. Hata et al.). 6. Cytoplasmic Ca 2+ response in pancreatic beta cells of the NON mouse (K. Tsuji et al.). 7. Changes of the K + channel of the pancreatic B cell in the NON mouse (T. Taminato et al.). 8. Lipoproteins, cholesterol and bile acids in the NON mouse (K. Uchida et al.). 9. Intranuclear filaments in the pancreatic B cells and abnormal glucose tolerance in the NON mouse (K. Yamamoto et al.). III. Characteristics of the Nephropathy in the NON Mouse. 10. Histopathological observation of the development of glomerular intracapillary deposits in the NON mouse (Y. Muraoka et al.). 11. Cell infiltration in various organs and dilation of the urinary tubule in the NON mouse (K. Tanigawa et al.). 12. Immunopathological observations of nephropathy and characterization of infiltrated lymphocytes (Y. Watanabe et al.). 13. Renal pathological findings and abnormal GTT (H. Wainai et al.). 14. Renal lesions and urinary bladder carcinogenesis (S. Mori et al.). Subject Index.