Part 1 Pathology induced by inflammatory cytokines: introduction, B. Ryffel; pathophysiologic alterations induced by tumour necrosis factor, D.F. Remick and S.L. Kunkel; "in vitro" and "in vivo" activity and pathophysiology of human interleukin-8 and related peptides, R. Zwahlen, et al; pathology of recombinant human transforming growth factor-B1 (rhTGF-B1) in rats and rabbits, T.G. Terrell, et al; pathology of recombinant murine interferon-g in mice and recombinant human interferon-g in cynomolgus monkeys, T.G. Terrell and J.D. Green. Part 2 Cytokine receptors: introduction, B. Ryffel; pharmacokinetic parameters and biodistribution of soluble cytokine receptors, C.A. Jacobs, et al; immunomodulation with soluble IFNG receptor - preliminary study, L. Ozmen, et al; TNF receptors distribution in human tissues, B. Ryffel, et al. Part 3 Role of cytokines in disease: tumour necrosis factor/cachectin (TNF) as an effector of T-cell depedendent immunopathology, D.E. Grau, et al; cytokines involved in pulmonary fibrosis, P.F. Piquet; immune-mediated injury in bacterial meningitis, K. Frei, et al; clinical experiences with alpha- and gamma- interferons, G.G. Steinmann, et al; clinical experience with escherichia coli rhGM-CSF, A.C. Stern and T.C. Jones.