Part 1 The presymtomatic diagnosis of serious untreatable disease: genetic aspects, Huntington's disease, genetics and the G8 market, P.M.Conneally et al; psychological aspects, genetic choices, presymptomatic testing for Huntington's disease, N.S.Wexler; legal aspects, genetic discrimination, P.Reilly. Part 2 Prenatal diagnosis of conditions of variable manifestations: alphalantirypsin deficiency, ethical aspects of prenatal diagnosis, D.W.Cox; sickle cell anemia, a perspective on prenatal diagnosis, C.F.Whitten. Part 3 The proper use of genetic information: the problem of access to genetic data, P.Reilly; genetic screening and genetic information in the work place, B.Knoppers and H.Guay; the use of genetic information in evaluation insurability, L.D.Jones. Part 4 Pilot studies of new genetic services: predicting patient receptivity, a need for pilot programs and cost-benefit analysis, P.T.Rowley.