Recent Advances in Hemodynamics and Blood Mimetics is a comprehensive compilation of recent developments in biofluid mechanics and biomimetics, covering topics such as numerical modeling, biomedical applications of microfluidics, biomimetic flows, biomedicine applications, and organ-on-chip technology. The book explores blood hemodynamics at different scales, including application to diseases, the relationship between blood biomechanics and rheology, the mimetization of blood properties at arterial and capillary level, including the study of blood mechanical and flow properties, flow and surface properties of blood cells, and mimetization of these same properties in fluid/particle systems.
These concepts are applied to the development of organ-on-chip to improve the replication of biological processes in the human body. The book organizes recent knowledge on hemodynamics and blood mimetics and is representative of the different lines of research in the field, showing an integrated view of blood biomechanics encompassing all scales to create a valuable resource where different research lines can be found and their principles understood.
Joao Mario Miranda is FCT Assistant Researcher at the Transport Phenomena Research Center (CEFT), Chemical Engineering Department, Engineering Faculty, University of Porto. Research activities are in the interface between fluid dynamics and biological applications. The main topics are biomimetic fluids, microcirculation, two phase flows in microdevices, hemodynamics, cell trapping and detection, biofouling and cell adhesion.
Currently, Joao Mario Miranda is working on the simulation of flow in the vicinity of biofilms, in the development of new blood analogues for in vitro experiments and in the study of cell trapping and detection methods to enrich the cell content of a sample for detection of bacteria by PNA-FISH. Diploma Engineer in Mechanical Engineering in 2001, MSc in Mechanical Engineering Energy in 2004 and PhD in Mechanical Engineering in 2009, Ana Moita is an assistant professor in the Portuguese Military Academy, where she is the chair of Fluid Dynamics and Thermodynamics, and a researcher in IN+, Instituto Superior Tecnico, Universidade de Lisboa. A.S. Moita developed a strong background in wettability modification strategies, including micro-and-nanostructuring techniques applied to surface modification. In the last years, she has deepened these activities for microscale applications, towards devising microfluidic devices for thermal (energy conversion) and biomedical applications. PI/co-Pi of several national and international projects she is the leading researcher at the Laboratory of Interfacial plus Microscale Phenomena in IN+, Instituto Superior Tecnico, since 2014. Currently she has several projects in collaboration with the industry including a large project with UFRJ - Brasil and Petrobras, towards the development of a microchannel based heat sink to cool high concentration photovoltaic pannels. Ana Moita has been an invited lecturer for seminars in several international and national universities, including in Faculdade de Engenharia de Sao Carlos, Universidade de S. Paulo, Brazil.
A.S. Moita received 4 awards/distinctions. She is a reviewer for numerous international conferences, more than 60 journals and 5 funding agencies (including ESA), being part of the scientific and/or technical committee of more thab16 international conferences/workshops. A.S. Moita published 7 book chapters, nearly 60 peer reviewed journal papers, more than 100 conference papers. She is Guest-Editor in 3 journals and part of the Editorial board of Experimental Thermal and Fluid Science, Elsevier. Tomohiro Fukui is an Associate Professor at the Department of Mechanical Engineering, Kyoto Institute of Technology (KIT). He received a PhD in Engineering from Tohoku Univ. (Japan). His main research interests include rheology in biofluid mechanics and biomedical engineering. Currently, he engages in collaborative research titled "Consideration to create functional fluids by means of smart control of suspended particles? with Tohoku University. He published more than 40 peer reviewed papers. Ziemowit Ostrowski studied at the Silesian University of Technology, Gliwice (Poland) and University of Rome I La Sapienza (Italy). MSc in 2000 in Mechanical Engineering on coupling heat transfer solutions. PhD in 2006 in Mechanical Engineering on the application of Proper Orthogonal Decomposition to the solution of inverse heat transfer problems. DSc (habilitation) in 2020 on heat transfer and thermoregulation in human tissues. Z.Ostrowski works as Associate Professor and since 2021 serves as Deputy Head of the Department for Science at the Department of Thermal Technology, Silesian University of Technology, Gliwice (Poland). Z. Ostrowski does research in Biomedical Engineering, Environmental Engineering, and Mechanical Engineering. Since 2013 coordinates research activities and is Head of the Biomedical Engineering Lab (biomed~lab) at the Department of Thermal Technology. From 2003-2004 he worked as Visiting Researcher at the University of Central Florida, Orlando, FL (USA) and from 2009-2010 as a Postdoctoral Researcher in the field of modelling of bio-heat transfer at Eindhoven University of Technology (The Netherlands). From 2013-2015 was a lecturer of Heat Transfer in the Applied Computational Mechanics (ACM) master program of the University of Applied Sciences Landshut (Germany).
He was a grantee of the Fulbright Commission, Foundation for Polish Science, and Polish Ministry of Science and Higher Education. Author and co-author of over 40+ journal articles (h-index=11 Scopus) and over 130 national and international conference papers. Author?of?1?book (monograph), 4?chapters in books and editor of 7 volumes of edited series. In 2018-2019 was an associate editor of the IPSE (T&F) journal. Co-author of 14 granted patents and 7 pending patent applications and 4 rejected patent applications (incl. 2?EPO pending applications). He currently is involved in several research projects, including Norway Grants funded research as WP leader in collaboration with NTNU, Norway. Rui A. Lima is an Associate Professor at the Dep. of Mechanical Eng., Univ. of Minho (UMinho), and a researcher at MEtRICs/UMinho and CEFT/FEUP, Univ. of Porto. He received a Dipl. Eng. in Mechanical Eng. from UMinho (Portugal), a MSc-Eng from Sheffield Univ. (U.K.) and a PhD in Engineering from Tohoku Univ. (Japan). He has a h-index=28 and more than 160 scientific papers (>2500 citations). He is a member of the editorial board of several scientific journals in the field of microfluidics and engineering such as: Micromachines, Processes, Advances in Mechanical Engineering
and WS Annual Review of Biomechanics. Currently he lectures several Master courses in Mechanical, Industrial and Biomedical Engineering and has been the Director of several Master and Doctoral courses such as the Master of Micro and Nanotechnologies and the Doctoral program "Leaders for Technological Industries" (MIT Portugal program). His main research interests include microfluidics, nanofluidics, microcirculation, organ-on-a-chip, biofabrication, blood analogue fluids and blood flow in biomedical microdevices.
Herausgeber*in
Assistant Researcher, Engineering Faculty Porto University, Portugal
Assistant Professor, Portuguese Military Academy/Researcher, IN+ Instituto Superior TecnicoDepartment of Exact Sciences and Engineering, Portuguese Military Academy/IN+ Instituto Superior Tecnico, Universidade de Lisboa, Portugal
Associate Professor, Kyoto Institute of Technology, Department of Mechanical Engineering, Kyoto Institute of Technology, Japan
Associate Professor, Deputy Head of Department; Head of Biomedical Engineering Laboratory, Department of Thermal Technology, Silesian University of Technology, Gliwice, Poland
Associate Professor, Department of Mechanical Engineering, University of Minho (MEtRICs) and CEFT/FEUP, Portugal
Section 1. Numerical methods
1. Patient specific hemodynamics
2. Two-phase flows (VOF method, Euler-euler methods, Euler-Lagrange methods)
3. Macroscopic rheological properties estimated from microstructure of particle suspension
4. Dissipative Coupling of Fluid and Immersed Objects for Modelling of Cells in Flow
5. Flow of blood cells in microfluidic channels: a dissipative particle dynamics simulation study
Section 2. Biomedical applications of microfluidics
6. Biomechanics of blood cells
7. Techniques to fabricate microparticles for hemodynamic applications
8. Hemodynamics in the Microcirculation and in Microfluidics
9. Applications of inertial microfluidics in biomedical research
10. Properties and applications of PDMS microfluidic devices
11. In vitro hemodynamics
Section 3. Biomimetics and bioinspired flows
12. Review on blood analogue fluids
13. Murray's Law in blood vessel networks
14. Mechanical behavior of bio-inspired systems
15. Flow in microfluidic systems using networks of bio-inspired soft valves
16. Biomimetics of the pulmonary environment in vitro
Section 4. Applications to biomedicine
17. Gas embolisms in small vessels - formation, vessel clogging, flow
18. Pathological Hemodynamics
19. Flow Visualizations in PDMS Cerebral Aneurysm Biomodel
20. Blood flow in a cerebral aneurysm
21. Mechanical characterization of pathological blood
Section 5. Micro and nano flow applications in organ on chips
22. PDMS surface modification for microfluidic devices and organ on chip platforms
23. Flow assessment and analysis of oxygen transport in an organ on chip platform
24. Micro/Nanomachines for biomedical applications
25. Effects of microneedle design parameters on hydraulic resistance
26. PDMS Microneedles for organ-on-chip platforms
