The desire to understand protein structure has been given new impetus by the explosive growth of biotechnology and the important role of proteins, natural and modified, in this technology. Protein molecules are machines, and protein engineering is opening up a whole new world of machinery on the molecular scale. This work is a simple, but in many ways detailed, introduction, to current knowledge, techniques, and applications. The volume is essentially in two parts, the first half covering a basic introduction to proteins appropriate at the undergraduate and early postgraduate level, which will prove a valuable teaching aid. The second half is a more advanced guide to concepts and methods, covering a range of aspects not previously collected in one volume. It will serve as a background reader and guide for advanced research study.
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
Maße
Höhe: 230 mm
Breite: 150 mm
ISBN-13
978-0-444-80681-9 (9780444806819)
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Schweitzer Klassifikation
Chapter 1. The nature of proteins. 2. The concept of primary structure. 3. The concept of conformation. 4. Protein function. 5. The example of lysozyme. 6. The special case of metalloproteins. 7. Biosynthesis and genetic manipulation. 8. Nature's protein engineering: the five billion year project. 9. Calculation of secondary structure from the amino acid sequence. 10. The calculation of tertiary structure: theory and methods. 11. The calculation of tertiary structure: results and conclusions. 12. Design of novel peptides and proteins in industry. 13. Engineering proteins against infection. Appendix 1. Stereoscopic pictures of the 20 amino acid residues. Appendix 2. List of proteins of known x-ray structure. Appendix 3. Illustrative bibliography of conformational engergy calculations.
