Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.
Rezensionen / Stimmen
"This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation." (Doody's, 21 October 2011)
Produkt-Info
Auflage
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Produkt-Hinweis
Fadenheftung
Gewebe-Einband
Maße
Höhe: 261 mm
Breite: 182 mm
Dicke: 28 mm
Gewicht
ISBN-13
978-0-8138-2993-7 (9780813829937)
Schweitzer Klassifikation
Jim Riviere, DVM, PhD, DSc (hon), ATS, is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology, Alumni Distinguished Graduate Professor, and Director of the Center for Chemical Toxicology Research and Pharmacokinetics at North Carolina State University, and Editor of the Journal of Veterinary Pharmacology and Therapeutics.
Autor*in
North Carolina State University, North Carolina, USA
Preface.
Chapter 1: Introduction.
Chapter 2: Principles of Drug Movement in the Body.
Chapter 3: Quantitative Structure Permeability Relationships (QSPeR).
Chapter 4: Absorption.
Chapter 5: Distribution.
Chapter 6: Renal Elimination.
Chapter 7: Hepatic Biotransformation and Biliary Excretion.
Chapter 8: Compartmental Models.
Chapter 9: Noncompartmental Models.
Chapter 10: Nonlinear Models.
Chapter 11: Physiological Models.
Chapter 12: Dosage Regimens.
Chapter 13: Simultaneous Pharmacokinetic-Pharmacodynamic Modeling.
Chapter 14: Study Design and Data Analysis.
Chapter 15: Design and Analysis of Bioequivalence Studies and FDA's in vitro/in vivo (IVIV).
Chapter 16: Population Pharmacokinetic Models and the Bayesian Forecasting Applied to Clincal Pharmacokinetics.
Chapter 17: Dosage Adjustments in Renal (and Hepatic) Disease.
Chapter 18: Interspecies Extrapolations.
Chapter 19: Tissue Residues and Withdrawal TimesAppendix
