The Dentate Gyrus and Its Role in Seizures

Name: The Dentate Gyrus and Its Role in Seizures | Epilepsy Research Supplements
Price: 207.82 EUR
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ISBN: 978-0-444-81447-0

Epilepsy Research Supplements

C.E. Ribak etc.C.M. Gall I. Mody(Herausgeber*in)

Elsevier (Verlag)

Erschienen im November 1992

Buch

Hardcover

336 Seiten

978-0-444-81447-0 (ISBN)

207,82 €inkl. 7% MwSt.

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Beschreibung

The chapters of this book are grouped to provide a logical sequence for the reader. The first section, entitled Cell Types and Innervation Patterns brings together six presentations that address different aspects of the detailed anatomy of the dentate gyrus. Particular emphasis is placed on the three major cell types, granule cells, basket cells and the heterogeneous cells of the hilus. In addition, two of the chapters focus on the termination pattern of chemically-identified afferents to this region. The section concludes with a paper that bridges the gap between anatomy and the next section: Cellular Physiology and Functional Plasticity of neurons in the dentate gyrus. The five chapters in the second section are devoted to the electrophysiology of different neuronal types of the dentate gyrus. The middle section, entitled Seizures and the Regulation of Gene Expression and Protein Content , demonstrates some remarkable alterations in the expression of neuropeptides, growth factors and intracellular calcium-regulating proteins in experimental models of epilepsy.

The chapters of this book are grouped to provide a logical sequence for the reader. The first section, entitled Cell Types and Innervation Patterns brings together six presentations that address different aspects of the detailed anatomy of the dentate gyrus. Particular emphasis is placed on the three major cell types, granule cells, basket cells and the heterogeneous cells of the hilus. In addition, two of the chapters focus on the termination pattern of chemically-identified afferents to this region. The section concludes with a paper that bridges the gap between anatomy and the next section: Cellular Physiology and Functional Plasticity of neurons in the dentate gyrus. The five chapters in the second section are devoted to the electrophysiology of different neuronal types of the dentate gyrus. The middle section, entitled Seizures and the Regulation of Gene Expression and Protein Content , demonstrates some remarkable alterations in the expression of neuropeptides, growth factors and intracellular calcium-regulating proteins in experimental models of epilepsy.

Weitere Details

Inhalt

Introduction. List of contributors. I. Cell types and innervation patterns. 1. Morphological variability and developmental aspects of monkey and human granule cells: Differences between the rodent and primate dentate gyrus (L. Seress). 2. Local circuitry of GABAergic basket cells in the dentate gyrus. (C.E. Ribak). 3. Synaptic connections of seizure-sensitive neurons in the dentate gyrus (C. Leranth, R. Nitsch, T. Deller, M. Frotscher). 4. cholinergic and GABAergic neurotransmission in the fascia dentata: Electron microscopic immunocytochemical studies in rodents and primates (M. Frotscher, E. Soriano, C. Leranth). 5. GABAergic septal and serotonergic median raphe afferents preferentially innervate inhibitory interneurons in the hippocampus and dentate gyrus (T.F. Freund). 6. Differentation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: Granule cells, spiny hilar cells, and aspiny "fast spiking" cells (H.E. Scharfman). II. Cellular physiology and functional plasticity. 7. Granule cell inhibition and the activity of hilar neurons (U. Misgeld, M. Bijak, H. Brunner). 8. GABA B receptors mediate disinhibition and facilitate long term potentation in the dentate gyrus (D.D. Mott, D.V. Lewis). 9. Noradrenergic modulation of epileptiform bursting and synaptic plasticity in the dentate gyrus (P.K. Stanton). 10. A peculiar form of potentiation in mossy fiber synapses (U. Staubli). 11. The electrophysiology of dentate gyrus granule cells in whole-cell recordings (I. Mody, G. Kohr, T.S. Otis, K.J. Staley). III. Seizures and the regulation of gene expression and protein content. 12. The dentate gyrus: a model system for studies of neurotrophin regulation (C. Gall, J. Lauterborn). 13. Hippocampal opioid peptides and seizures (J.S. Hong). 14. Seizures and the regulation of glial gene expression (O. Steward, E.R. Torre, R. Tomasulo, E. Lothman). 15. Calcium binding proteins in the dentate gyrus (K.G. Baimbridge). IV. Plasticity in human and experimental epilepsy. 16. Morphological changes in the dentate gyrus (C.R. Houser). 17. Neurotransmitters and their receptors in human temporal lobe epilepsy (N.C. de Lanerolle, M. Brines, A. Williamson, J.H. Kim, D.D. Spencer). 18. Assessing the functional significance of mossy fiber sprouting (T.P. Sutula, G. Golarai, J. Cavazos). 19. Long-term potentiation and sprouting of mossy fibers produced by brief episodes of hyperactivity (A. Repressa, Y. Ben-Ari). V. Integrative physiology: Why a dentate gyrus? 20. The dentate gyrus as a regulated gate for the propagation of epileptiform activity (U. Heinemann, H. Beck, J.P. Dreier, E. Ficker, J. Stabel and C.L. Zhang). 21. Physiological function of granule cells: a hypothesis (G. Buzsaki, G. Czeh). 22. Information processing in the dentate gyrus (R.E. Hampson, S.A. Deadwyler). 23. The dentate gyrus as a control point for seizures in the hippocampus and beyond (E.W. Lothman, J.L Stringer, E.H. Bertram). Subject Index.

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