Biological Oxidation Systems, Volume II discusses the various antioxidants and antioxidant enzymes that play significant roles in protecting cells from deleterious reactions between their structural/functional components and the free radicals. This book examines the myriad chemical reactions of a cell's metabolic activity that produce a variety of free radicals. Comprised of three parts encompassing 35 chapters, this volume starts with an overview of the metabolism of xenobiotics during arachidonic acid metabolism. This book then discusses the various causes of human cancers and diseases, which include exposure to environmental chemicals and other toxicants. This text considers the dietary habits and nutritional factors that play an important role in the causation and development of several human cancers, including cancer of the breast, colon, prostate, and other organs. Other chapters discuss the toxic effects of several xenobiotics that involve free-radical mechanisms. Biochemists, biophysicists, microbiologists, organic chemists, food chemists, and medical scientists will find this book extremely useful.
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Elsevier Science Publishing Co Inc
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
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ISBN-13
978-0-12-584552-6 (9780125845526)
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Foreword
Preface
VI. Oxidation Mechanisms in Carcinogenesis
Oxidations Catalyzed by Prostaglandin H Synthase
Oxidation Reactions by Endoperoxide Synthase
Molecular Mechanisms for the Peroxidase Catalyzed Activation of Arylamine Carcinogens to Cytotoxic Metabolites
Inhibitors of Carcinogenesis
The Role of Iron in Asbestos-Catalyzed Damage to Lipids and DNA
Selective Enhancement of Free Radicals by cis-Unsaturated Fatty Acids in Tumor Cells as a Strategy to Kill Tumor Cells In Vitro and In Vivo
Inhibition of Binding of Aflatoxin ?1 to Renal DNA by Dehydroepiandrosterone
VII. Enzymes in Prostaglandin and Leukotriene Metabolism
Prostaglandin H Synthase
Peroxide Tone and Its Consequences
Involvement of Glutathione Peroxidases in Prostaglandin Biosynthesis
Non-Cyclooxygenase Prostaglandin Biosynthesis: Formation of PGA3 Isomers Via an Allene Oxide
Non-Cyclooxygenase Oxidative Formation of a Series of Novel Prostaglandins: Ramifications for the Measurement of Eicosanoids in Biological Fluids
Lipoxins: Bioactive Eicosanoids Generated by Lipoxygenase Interactions
Novel Hepoxilin Glutathione Conjugates with Biological Activity
Optically Pure Allylic Hydroperoxides: Mechanisms for Hydroperoxide Rearrangements
Arachidonate 12-Lipoxygenases
The Unique Characteristics of the Purified 5-Lipoxygenase from Potato Tubers and the Proposed Mechanism of Formation of Leukotrienes and Lipoxins
Arachidonic Acid Oxidation and Platelet Function
Role of Eicosanoids of the Lipoxygenaese Pathway in Vertebrate Reproduction
Endogenous Formation of Leukotriene C4 In Vivo and Characterization of Novel Metabolites Formed In Vitro and In Vivo
VIII. Lipid Peroxidation and Other Nonenzymatic Reactions of Oxygen
Vitamin E In Vivo
Interaction of Glutathione and a-Tocopherol in the Inhibition of Lipid Peroxidation in Rat Liver Microsomes
Glutathione and Vitamin E and the Control of Lipid Peroxidation of Rat Liver Nuclei
Mechanisms of Vitamin E Control of Lipid Peroxidation: Regeneration, Synergism, Asymmetry, Migration, and Metal Chelation
Vanadium as a Biological Hydrogen-Abstractive Agent
Constitutive and Inducible Repair Systems in Oxidative Stress
Oxidative Damage to Proteins Mediated by Singlet Oxygen
Molecular Mechanisms of Oxidative Cell Damage
Oxidative Myocardial Injury and Cardiac-Derived Experimental Systems
Mitochondrial Generation of Hydroxyl Radical During Reperfusion of Ischemic Myocardium
Role of Lipid Peroxides in Aging
Hepatocellular Regeneration as a Determinant of Halomethane Hepatotoxicity
Structure Activity Correlations of 1,4-Dihydropyridines as Reducing Agents
Modulation of Tubulin Tyrosinolation in Human Neutrophils by the NADPH Oxidase-Mediated Respiratory Burst
Isolation and Characterization of a Mammalian Hydroxyacid-Oxoacid Transhydrogenase
Author Index
Key Word Index
Symposium Delegates
