Editorial: Rauch, A.; Molecular and Clinical Aspects of Angelman Syndrome: Dagli, A.; Buiting, K.; Williams, C.A.; Rett Syndrome: Smeets, E.E.J.; Pelc, K.; Dan, B.; MECP2 Duplication Syndrome: Van Esch, H.; CDKL5-Related Disorders: From Clinical Description to Molecular Genetics: Bahi-Buisson, N.; Bienvenu, T.; FOXG1-Related Disorders: From Clinical Description to Molecular Genetics: Florian, C.; Bahi-Buisson, N.; Bienvenu, T.; The MEF2C-Related and 5q14.3q15 Microdeletion Syndrome: Zweier, M.; Rauch, A.; Pitt-Hopkins Syndrome: Peippo, M.; Ignatius, J.; Severe Intellectual Disability Associated with Recessive Defects in CNTNAP2 and NRXN1: Zweier, C.; The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome): Phelan, K.; McDermid, H.E.; Update on Kleefstra Syndrome: Willemsen, M.H.; Vulto-van Silfhout, A.T.; Nillesen, W.M.; Wissink-Lindhout, W.M.; van Bokhoven, H.; Philip, N.; Berry-Kravis, E.M.; Kini, U.; van Ravenswaaij-Arts, C.M.A.; Delle Chiaie, B.; Innes, A.M.M.; Houge, G.; Kosonen, T.; Cremer, K.; Fannemel, M.; Stray-Pedersen, A.; Reardon, W.; Ignatius, J.; Lachlan, K.; Mircher, C.; Helderman van den Enden, P.T.J.M.; Mastebroek, M.; Cohn-Hokke, P.E.; Yntema, H.G.; Drunat, S.; Kleefstra, T.; Mild to Moderate Intellectual Disability and Significant Speech and Language Deficits in Patients with FOXP1 Deletions and Mutations: Horn, D.; Adult Phenotypes in Angelman- and R ett-Like Syndromes: Willemsen, M.H.; Rensen, J.H.M.; van Schrojenstein-Lantman de Valk, H.M.J.; Hamel, B.C.J.; Kleefstra, T.; Author Index.