Part 1 Historical perspectives: history and role of guidelines and guidance of drug evaluation, Jerome Levine; decision processes in establishing the efficacy and safety of psychotropic drugs, Louis Lasagna. Part 2 General principles in the evaluation of psychotropic drugs: design issues for the clinical evaluation of psychotropic drugs, Eugene M. Laska et al; classification issues in patient selection and description, Jean Endicott et al; assessment and measurement of clinical change, A. John Rush et al; pharmacologic considerations, David J. Grenblatt et al; statistical issues for the clinical evaluation of psychotropic drugs, Philip W. Lavori et al; clinical trial implementation, Ronald Kartzinel et a; premarketing safety evaluation of psychotropic drugs, Thomas P. Laughren et al; post-marketing surveillance of drugs, Leo E. Hollister et al; documenting and reporting the study results of a randomized clinical trial (spicy meatballs, not pabulum), David J. Kupfer et al; ethical and legal considerations in drug trials, Don Gallant and Susan Krinsky. Part 3 Specific patient groups - application of general methodologic principles: evaluating drug treatments of depressive disorders, Gerals L. Klerman et al; evaluating pharmacologic treatments for bipolar disorder, Alan J. Gelenberg et al; methods for clinical evaluation of pharmacologic treatments of schizophrenia, John M. Kane et al; evaluating drug treatments of generalized anxiety disorder and adjustment disorders with anxious mood, Karl Rickels et al; evaluation of psychotropic drug treatment of panic-related disorders and social phobia, Donald F. Klein et al; obsessive-compulsive disorder, Wayne K. Goodman et al; methods for the evaluation of pharmacologic agents in the treatment of cognitive and other deficits in dementia, Samuel Gershon et al; clinical trials in children and adolescents, Rachel G. Klein et al; evaluation of pharmacolocig treatments in eating disorders, Katherine A. Hamli et al; evaluation of hypnotic medications, Thomas Roth et al; establishing the efficacy and safety of medications for the treatment of drug dependence and abuse - methodologic issues, Jack D. Blaine et al; evaluation of pharmacological treatments for alcohol abuse, dependence and their complications, Markku Linnoila et al; evaluation of pharmacologic treatments in personality disorders, Paul H. Soloff et al.
