Preface (F. Pisani, E. Perucca, G. Avanzini, A. Richens). Introduction (R. Di Perri, D. Janz). General Aspects. Chapter 1. Mental deterioration in a population with intractable epilepsy (H. Meinardi, A.M. Beun, B. Aldenkamp, B. Nunes, M. Engelsman, E. Forceville). Chapter 2. The influence of antiepileptic drugs on the natural history of epilepsy (E.H. Reynolds). Experimental Aspects. Chapter 3. Rational basis for the development of new antiepileptic drugs (R. Mutani, R. Cantello, M. Gianelli, D. Bettucci). Chapter 4. Genetic animal models for generalized non convulsive epilepsies and new antiepileptic drugs (G. Avanzini, C. Marescaux). Chapter 5. Excitatory amino acids in epilepsy and novel anti-epileptic drugs (A.G. Chapman, B.S. Meldrum). Chapter 6. Anticonvulsant activity of some calcium antagonists in genetically epilepsy prone rats (G. De Sarro, G.R. Trimarchi, R. Federico, A. De Sarro). Chapter 7. The brain distribution of old and new antiepileptic drugs (F. Monaco, G. Sechi). Clinical Aspects. Chapter 8. Evaluation of clinical efficacy in antiepileptic drugs trials (D. Schmidt). Chapter 9. Pharmacokinetics and interactions of the new antiepileptic drugs (E. Perucca, F. Pisani). Chapter 10. The efficacy and safety of new antiepileptic drugs (A. Richens). The New Antiepileptic Drugs. Chapter 11. Eterobarb (K.D. Wolter). Chapter 12. Felbamate (R. Duane Sofia, L. Kramer, J.L. Perhach, A. Rosenberg). Chapter 13. Gabapentin (M. Foot, J. Wallace). Chapter 14. Lamotrigine (A.W.C. Yuen). Chapter 15. Loreclezole (F. De Beukelaar, L. Tritsmans). Chapter 16. Losigamone (U. Stein, K. Klessing, S.S. Chatterjee). Chapter 17. Oxcarbazepine (P. Klosterskov-Jensen, L. Gram, M. Schmutz). Chapter 18. Ralitoline (H. Anhut, G. Satzinger, A. Von Hodenberg). Chapter 19. Remacemide (K.T. Muir, G.C. Palmer). Chapter 20. Stiripentol (J.C. Vincent). Chapter 21. Tiagabine (M.W. Pierce, P.D. Suzdak, L.E. Gustavson, H.B. Mengel, J.F. McKelvy, T. Mant). Chapter 22. Vigabatrin (J.P. Mumford, P.J. Lewis). Chapter 23. Zonisamide (M. Seino, H. Miyazaki, T. Ito). Recent Clinical Trials. Chapter 24. Kinetics, metabolism and effects of carbamazepine-10,11-epoxide in man (T. Tomson, L. Bertilsson). Chapter 25. Gabapentin (D. Chadwick). Chapter 26. Lamotrigine in refractory epilepsy: a long-term open study (F. Pisani, M. Russo, R. Trio, C. Artesi, A. Fazio, G. Oteri, R. Di Perri). Chapter 27. Vigabatrin (R. Michelucci, C.A. Tassinari).
